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Hippocampal volume in adolescent-onset alcohol use disorders.
OBJECTIVE Alcohol use disorders (defined as DSM-IV alcohol dependence or abuse) are prevalent and serious problems among adolescents. As adolescence is marked by progressive hippocampal development,Expand
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Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders.
BACKGROUND In adults, prefrontal, thalamic, and cerebellar brain injury is associated with excessive ethanol intake. As these brain structures are actively maturing during adolescence, weExpand
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Structural brain abnormalities in borderline personality disorder: A voxel-based morphometry study
Imaging studies using region-of-interest morphometry and positron emission tomography have contributed to our understanding of structural and functional abnormalities in borderline personalityExpand
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Characteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative study.
OBJECTIVE Suicidal behavior is highly prevalent in borderline personality disorder and major depressive episode, although the characteristics of suicide attempts in the two disorders are believed toExpand
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Impulsivity and prefrontal hypometabolism in borderline personality disorder
Prefrontal hypoperfusion and decreased glucose uptake in the prefrontal cortex (PFC) are found in violent criminal offenders, murderers and aggressive psychiatric patients. These abnormalities may beExpand
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Structural brain abnormalities and suicidal behavior in borderline personality disorder.
BACKGROUND Structural brain abnormalities have been demonstrated in subjects with BPD in prefrontal and fronto-limbic regions involved in the regulation of emotion and impulsive behavior, executiveExpand
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Anatomical MRI study of borderline personality disorder patients
Hippocampal volume reduction has been reported in patients with borderline personality disorder (BPD), and is hypothesized to be associated with traumatic childhood experiences. We extended thisExpand
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A fenfluramine-activated FDG-PET study of borderline personality disorder
BACKGROUND Impulsive aggression in patients with personality disorders is associated with diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to serotonergicExpand
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Risk factors for suicidal behavior in borderline personality disorder.
OBJECTIVE This study identified potential risk factors for suicidal behavior in patients with borderline personality disorder defined by the Diagnostic Interview for Borderline Patients and byExpand
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Childhood abuse as a risk factor for suicidal behavior in borderline personality disorder.
A childhood history of sexual or physical abuse is highly prevalent in borderline personality disorder (BPD) and is associated with self-destructive behavior in clinical and nonclinical samples.Expand
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