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An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines.
An extremely convenient procedure for the determination of amines, amino acids, and proteins where the quenching step employed by previous investigators has been eliminated is described, which has a greater sensitivity than previously described techniques employing TNBS. Expand
Differential Effect of Parenteral Zinc on the Course of Various Bacterial Infections 1
Intraperitoneal pretreatment of rats with zinc, as zinc chloride, 1 hr prior to bacterial challenge with S. typhimurium, F. tularensis, or S. pneumoniae enhanced mortality incidence in S. Typhooni infection only and single and multiple zinc treatments enhanced survival incidence during the early postinfection period in rats infected with F. Tularensis or S pneumoniae. Expand
Involvement of hepatic metallothioneins in hypozincemia associated with bacterial infection.
Hypozincemia was induced in rats by Salmonella typhimurium and live vaccine strain Francisella tularensis infections and provides evidence that metallothioneins not only have the previously postulated regulatory role in normal zinc homeostasis but are intimately involved in the zinc redistribution occurring during the acute stage of infectious illness. Expand
Role of zinc in the abatement of hepatocellular damage and mortality incidence in endotoxemic rats
Protection afforded by ZnIP treatment results as a consequence of the ability of zinc to diminish absorption of the toxin from the peritoneal cavity and subsequent hepatic uptake is indicated. Expand
Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.
Summary The method used permits correction for the influence of the neutral hexoses, galactose and mannose, on the apparent concentration of protein-bound l-fucose, as estimated by theExpand
Possible relation of prostaglandins to PMN-derived mediators of host metabolic responses to inflammation.
It is suggested that prostaglandin synthesis has a function in production of mediators by stimulated-PMN preparations that mediate plasma zinc depression, hepatic amino acid uptake, and increased numbers of blood neutrophils. Expand
Effect of leukocytic endogenous mediators on endocrine pancreas secretory responses.
Plasma insulin and glucagon responses to crude LEM may explain increases in hepatic cAMP, uptake of AA, and glycogenolysis as well as hypoglycemia, and implicate the endocrine pancreas as a factor regulating the host's metabolic response to infection. Expand
Results suggest that glucagon, but not LEM, may be a common mediator in MT response during inflammatory stress, and this cysteine-rich metalloprotein occurs through the action of some common mediators. Expand
In vitro and in vivo actions of zinc ion affecting cellular substances which influence host metabolic responses to inflammation
The effect of Zn2+ on mediator production and PG synthesis was examined because Zn homeostasis is perturbed during infection, Zn is known to regulate some cellular functions, and there appears to be an interrelationship between PG synthesis and mediators. Expand
The toxicity of Sn-pyrophosphate: clinical manifestations prior to acute LD50.
Evaluation of the toxic effects of phosphate agents should not be limited to determination of LD/sub 50/ alone but should include appropriate biochemical measurements in blood, as this phenomenon appears to be the primary clinical manifestation following the administration of large amounts of technetiumSn-phosphate compounds in rats. Expand