• Publications
  • Influence
Correcting for purifying selection: an improved human mitochondrial molecular clock.
TLDR
A modest effect of purifying selection on the mtDNA coding region is confirmed and an improved molecular clock for dating human mtDNA is proposed, based on a worldwide phylogeny of > 2000 complete mtDNA genomes and calibrating against recent evidence for the divergence time of humans and chimpanzees. Expand
A mitochondrial stratigraphy for island southeast Asia.
TLDR
It is demonstrated that mitochondrial DNA diversity in the region is extremely high and includes a large number of indigenous clades, suggesting that, if an agriculturalist migration did take place in ISEA, it was demographically minor, at least with regard to the involvement of women. Expand
The Archaeogenetics of Europe
TLDR
The new chronology and compare mtDNA with Y-chromosome patterns are reviewed and what is learnt from archaeogenetics concerning five episodes over the past 50,000 years is summarized. Expand
Mitochondrial genomes from modern horses reveal the major haplogroups that underwent domestication
TLDR
Now that the major horse haplogroups have been defined, each with diagnostic mutational motifs (in both the coding and control regions), these haplotypes could be easily used to classify well-preserved ancient remains, assess the haplogroup variation of modern breeds, and evaluate the possible role of mtDNA backgrounds in racehorse performance. Expand
Phylogeography and ethnogenesis of aboriginal Southeast Asians.
TLDR
Analysis of mitochondrial DNA genome sequences from Peninsular Malaysia suggests an ancestry in Indochina around the time of the Last Glacial Maximum, followed by an early-Holocene dispersal through the Malay Peninsula into island Southeast Asia. Expand
Genetic and archaeological perspectives on the initial modern human colonization of southern Asia
TLDR
This work presents an alternative model based on a combination of genetic analyses and recent archaeological evidence from South Asia and Africa that supports a coastally oriented dispersal of modern humans from eastern Africa to southern Asia ∼60–50 thousand years ago (ka). Expand
Climate change and postglacial human dispersals in southeast Asia.
TLDR
It is shown that haplogroup E, an important component of mtDNA diversity in the region, evolved in situ over the last 35,000 years and expanded dramatically throughout ISEA around the beginning of the Holocene, at the time when the ancient continent of Sundaland was being broken up into the present-day archipelago by rising sea levels. Expand
The Expansion of mtDNA Haplogroup L3 within and out of Africa.
TLDR
The similarity of the age of L3 to its two non-African daughter haplogroups, M and N, suggests that the same process was likely responsible for both the L3 expansion in Eastern Africa and the dispersal of a small group of modern humans out of Africa to settle the rest of the world. Expand
Comparing phylogeny and the predicted pathogenicity of protein variations reveals equal purifying selection across the global human mtDNA diversity.
TLDR
No measurable difference is found in this measure of purifying selection in mtDNA across the global population, represented by the macrohaplogroups L, M, and N. Expand
Ancient voyaging and Polynesian origins.
TLDR
It is shown that the "Polynesian motif itself most likely originated >6 ka in the vicinity of the Bismarck Archipelago, and its immediate ancestor is >8 ka old and virtually restricted to Near Oceania, which indicates that Polynesian maternal lineages from Island Southeast Asia gained a foothold in Near OCEania much earlier than dispersal from either Taiwan or Indonesia would predict. Expand
...
1
2
3
4
5
...