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Axotomy- and autotomy-induced changes in the excitability of rat dorsal root ganglion neurons.
The onset of autotomy coincided with alterations in the excitability of large, putative nonnociceptive, neurons, whereas small cells from the autotomy group were only slightly more excitable, consistent with the hypothesis that the onset of Autotomy is associated with changes in the properties of myelinated fibers. Expand
Axotomy- and autotomy-induced changes in Ca2+ and K+ channel currents of rat dorsal root ganglion neurons.
The data suggest that axotomy-induced increases in excitability are associated with decreases in I(K) and/or decreases in g(K,Ca) that are secondary to decreased Ca2+ influx, and supports the hypothesis that autotomy, that may be related to human neuropathic pain, is associated with changes in the properties of large myelinated sensory neurons. Expand
Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells.
Data from microfluorimetric and patch-clamp techniques are consistent with a central role for mitochondrial oxidative phosphorylation in coupling changes in glucose concentration with the secretion of insulin. Expand
Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle
The Kir6.2/SUR channel complex comprises the ATP‐sensitive K‐channel, which is strongly expressed in brain, skeletal muscle, cardiac muscle and in insulinoma cells, weakly expressed in lung and kidney and not detectable in spleen, liver or testis. Expand
Axotomy Reduces the Effect of Analgesic Opioids Yet Increases the Effect of Nociceptin on Dorsal Root Ganglion Neurons
Data suggest that the functional downregulation of μ-opioid receptors on sensory nerves contributes to the poor efficacy of opioids in neuropathic pain and the spinal administration of nociceptin or agonists that activate ORL1(opIOid-like orphan receptor) may prove to be of clinical interest in the management of neuropathicPain. Expand
Endocytosis of secretory granules in mouse pancreatic beta‐cells evoked by transient elevation of cytosolic calcium.
The data indicate that in the pancreatic beta‐cell, exocytosis and endocytosi are regulated by different mechanisms, suggesting that aggregates of granules are connected to the plasma membrane by a single pore and are subsequently retrieved as a single unit. Expand
Permeation and gating properties of the L-type calcium channel in mouse pancreatic beta cells
The results suggest that the high divalent cation solutions usually used to record single L-type Ca2+ channel activity produce a positive shift in the voltage dependence of activation (approximately 32 mV in 100 mM Ba2+). Expand
Effects of substance P on excitability and ionic currents of normal and axotomized rat dorsal root ganglion neurons
The effects of SP on the I–V relationship were similar in control and in axotomized neurons and the altered sensitivity of ‘small’ and ‘large’ cells could not be attributed to axotomy‐induced changes in input resistance or membrane potential. Expand
Involvement of Ras/MAP kinase in the regulation of Ca2+ channels in adult bullfrog sympathetic neurons by nerve growth factor.
NGF-induced increase in Ca2+ channel current in adult sympathetic neurons results, at least in part, from new channel synthesis after Trk activation of Ras and mitogen activated protein kinase by a mechanism that is independent of extracellular Ca2+. Expand
Block of ATP‐regulated and Ca2(+)‐activated K+ channels in mouse pancreatic beta‐cells by external tetraethylammonium and quinine.
1. The whole‐cell and outside‐out patch configurations of the patch‐clamp technique were used to investigate the effects of extracellular tetraethylammonium ions (TEA+) and quinine on bothExpand