P. Smith

Publications109
h-index21
Citations1,194
Highly Influential Citations31
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Designer biomass for next-generation biorefineries: leveraging recent insights into xylan structure and biosynthesis
Xylans are the most abundant noncellulosic polysaccharides in lignified secondary cell walls of woody dicots and in both primary and secondary cell walls of grasses. These polysaccharides, which… Expand
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Insights into the role of heme in the mechanism of action of antimalarials.
By using cell fractionation and measurement of Fe(III)heme-pyridine, the antimalarial chloroquine (CQ) has been shown to cause a dose-dependent decrease in hemozoin and concomitant increase in toxic… Expand
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In vitro culture and cryopreservation of Uronema marinum isolated from farmed New Zealand groper (Polyprion oxygeneios).
An in vitro culture method was developed for the ciliated protozoa Uronema marinum isolated from New Zealand aquacultured groper (Polyprion oxygeneios). Both formulated media and sterile seawater… Expand
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Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion
Fertilization increases both cytosolic Ca2+ concentration and oxygen consumption in the egg but the relationship between these two phenomena remains largely obscure. We have measured mitochondrial… Expand
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Visual Culture Studies versus Art Education
A merican visual arts education is in crisis. Hearing this, art educators of my advanced years would ordinar, i ly merely roll their eyes and murmu,r, ’So, what else is new?’ In a time when every… Expand
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Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.
A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium… Expand
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Antiplasmodial and Cytotoxic Activities of Drimane Sesquiterpenes from Canella winterana
The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 μg/mL). Bioassay… Expand
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Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance…
A series of 4-amino-7-chloroquinolines with dibenzylmethylamine (dibemethin) side chains were shown to inhibit synthetic hemozoin formation. These compounds were equally active against cultures of… Expand
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Artemisinin-quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity.
Novel artemisinin-quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90-110°C). All compounds were obtained as the β-isomers and… Expand
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Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents.
New polynuclear organometallic Platinum Group Metal (PGM) complexes containing di- and tripyridyl ester ligands have been synthesised and characterised using analytical and spectroscopic techniques… Expand
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