P. Smircich

Publications27
h-index11
Citations520
Highly Influential Citations20
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Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi
BackgroundDue to the absence of transcription initiation regulation of protein coding genes transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the majority of gene… Expand
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Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica
BackgroundThe common liver fluke Fasciola hepatica is the agent of a zoonosis with significant economic consequences in livestock production worldwide, and increasing relevance to human health in… Expand
  • 57
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Functional Genomic Characterization of mRNAs Associated with TcPUF6, a Pumilio-like Protein from Trypanosoma cruzi*
Trypanosoma cruzi is the protozoan parasite that causes Chagas disease or American trypanosomiasis. Kinetoplastid parasites could be considered as model organisms for studying factors involved in… Expand
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Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands… Expand
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Trypanosoma cruzi: molecular characterization of TcPUF6, a Pumilio protein.
In trypanosomes regulation of gene expression occurs mainly at the post-transcriptional level. Pumilio proteins are RNA-binding proteins that modulate gene expression in lower and higher eukaryotes.… Expand
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DNA conformational changes and cleavage by ruthenium(II) nitrofurylsemicarbazone complexes.
Metal complexes that establish interactions with DNA are being studied not only because of their potential use as therapeutic agents but also as tools for biochemistry and molecular biology.… Expand
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A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed in Echinococcus multilocularis Stem Cells
Taeniid cestodes (including the human parasites Echinococcus spp. and Taenia solium) have very few mobile genetic elements (MGEs) in their genome, despite lacking a canonical PIWI pathway. The MGEs… Expand
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Pleiotropic alterations in gene expression in Latin American Fasciola hepatica isolates with different susceptibility to drugs
BackgroundFasciola hepatica is the main agent of fasciolosis, a zoonotic disease affecting livestock worldwide, and an emerging food-borne disease in humans. Even when effective treatments are… Expand
  • 10
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The miRnome of Fasciola hepatica juveniles endorses the existence of a reduced set of highly divergent micro RNAs in parasitic flatworms.
The liver fluke Fasciola hepatica is a foodborne zoonotic parasite affecting livestock worldwide, with increasing relevance in human health. The first developmental stage that the host meets after… Expand
  • 9
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Recurrent dissemination of SARS-CoV-2 through the Uruguayan-Brazilian border
Summary Background: Uruguay is one of the few countries in the Americas that successfully contained the COVID-19 epidemic during the first half of 2020. Nevertheless, the intensive human mobility… Expand
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