Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- BiologyNature
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, T. Frayling
- BiologyNature Genetics
- 8 September 2014
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, K. Mohlke
- BiologyNature
- 16 December 2014
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Identification of seven loci affecting mean telomere length and their association with disease
A genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals supports a causal role of telomere-length variation in some age-related diseases.
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- K. Estrada, U. Styrkársdóttir, F. Rivadeneira
- BiologyNature Genetics
- 9 April 2012
Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
- S. Wahl, A. Drong, J. Chambers
- BiologyNature
- 21 December 2016
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory…
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
- J. Kettunen, A. Demirkan, M. Ala-Korpela
- BiologyNature Communications
- 23 March 2016
The LPA locus link with cardiovascular risk exemplifies how detailed metabolic profiling may inform underlying aetiology via extensive associations with very-low-density lipoprotein and triglyceride metabolism and strengthens the argument for safe LPA-targeted intervention to reduce cardiovascular risk.
The transcriptional landscape of age in human peripheral blood
- M. Peters, R. Joehanes, A. Johnson
- BiologyNature Communications
- 22 October 2015
Differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index and the transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models.
Genetic determination of telomere size in humans: a twin study of three age groups.
- P. Slagboom, S. Droog, D. Boomsma
- BiologyAmerican Journal of Human Genetics
- 1 November 1994
The individual differences in mean TRF length in blood, therefore, seem to a large extent to be genetically determined.
Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
- L. Broer, V. Codd, D. Boomsma
- PsychologyEuropean Journal of Human Genetics
- 1 October 2013
A high and very consistent heritability estimate for TL is found, evidence for a maternal inheritance component and the influence of parental age at birth on TL is investigated, and a positive association with paternal age is found.
...
...