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Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.
TLDR
A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column that automatically eliminates interference from other compounds normally present in urine and other biological fluids is described. Expand
Gender- and smoking-related bladder cancer risk.
TLDR
The risk of bladder cancer in women who smoked was statistically significantly higher than that in men who smoked comparable numbers of cigarettes, and the slopes of the linear regression lines of the 3- and 4-ABP--hemoglobin adducts by cigarettes per day were statistically significantly steeper in women than in men. Expand
Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B1 intake and urinary excretion of aflatoxin M1.
TLDR
From the slope of the regression line for adduct level as a function of intake, it was calculated that 1.4-2.3% of ingested AFB1 becomes covalently bound to serum albumin, a value very similar to that observed when rats are administered AFB1. Expand
Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers.
TLDR
The finding of 4-ABP adducts in all nonsmokers was not anticipated but is consistent with low-level ubiquitous contamination of air, food, or water. Expand
Protein adducts in the molecular dosimetry of chemical carcinogens.
TLDR
This commentary reviews the development of molecular dosimetry based on protein adducts and describes some of the principles involved, which indicate that a high degree of specificity is characteristic of many carcinogen-protein interactions. Expand
Carotenoids/vitamin C and smoking‐related bladder cancer
TLDR
The protective effect of carotenoids on bladder cancer seemed to be influenced by NAT1 genotype, NAT2 phenotype and CYP1A2 phenotype; the association was mainly confined to subjects possessing the putative NAT1‐rapid, NAT1-rapid and CYF2‐rapids genotype/phenotype. Expand
Isolation and characterization of the major serum albumin adduct formed by aflatoxin B1 in vivo in rats.
TLDR
The spectral data strongly support a structure in which the terminal dihydrofuran ring of AFB1 has been converted to a pyrrolinone ring, and it is proposed that the initial adduct is formed by condensation of the dialdehyde tautomer of 8,9-dihydro-8, 9- dihydroxy-AFB1, with the epsilon-amino group of lysine, to form a Schiff base. Expand
Oxidation of 2,6-dimethylaniline by recombinant human cytochrome P450s and human liver microsomes.
TLDR
Results presented here suggest much of the observed interindividual variability of 2,6-DMA hemoglobin adduct levels could be due to differences in the relative amounts of hepatic 2E1 and 2A6. Expand
Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in White, African-American, and Asian-American men in Los Angeles County.
TLDR
The urinary excretion levels of PhIP were not associated with intake frequencies of any cooked meat based on a self-administered dietary questionnaire, in contrast to the earlier finding of a positive and statistically significant association between bacon intake and the urinary level of MeIQx. Expand
Arylamine exposures and bladder cancer risk.
TLDR
Results support the notion that arylamines contained in cigarette smoke and permanent hair dyes are human carcinogens and women may experience higher bladder cancer risk than men from comparable arieslamine exposure, possibly due in part to women's higher propensity for aRYlamine activation relative to men. Expand
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