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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.
Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in the expression of these enzymes may beExpand
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Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel.
Successful cryopreservation of freshly isolated hepatocytes would significantly decrease the need for freshly-procured livers for the preparation of hepatocytes for experimentation. Hepatocytes canExpand
  • 153
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Changes in adenosine sensitivity in the hippocampus of rats with streptozotocin‐induced diabetes
1 Hippocampal slices have been used to assess the sensitivity of the CNS to adenosine and γ‐aminobutyric acid (GABA) in diabetes. The effects of adenosine, 2‐chloroadenosine, GABA, muscimol andExpand
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Sex steroid induced changes in hepatic enzymes.
Sex differences exist in steroid and xenobiotic metabolism in the liver of a number of species. In the rat, the differences are regulated through the hypothalamo-pituitary axis. The previouslyExpand
  • 295
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In Vitro Effect of Fenugreek Extracts on Intestinal Sodium-dependent Glucose Uptake and Hepatic Glycogen Phosphorylase A
Fenugreek (Trigonella foenum-graecum L. seed) is a food with traditional medicinal use in diabetes. Beneficial effects have been demonstrated in diabetic animals and both insulin-dependent andExpand
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Prolactin-like immunoreactivity: localization in nerve terminals of rat hypothalamus.
Antibodies to rat prolactin were used in immunohistochemical studies of the hypothalamus and preoptic area of the rat. Evidence was obtained that a protein immunochemically related to prolactin wasExpand
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Feminization of hepatic S metabolism in male rats with a transplanted (MtT/F4)
After transplantation of MtT/F4 pituitary tumor cells to male rats of the Fisher strain, the masculine type of hepatic steroid metabolism was changed into a feminine pattern of enzyme activities.Expand
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Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-Solutions?
  • P. Skett
  • Biology, Medicine
  • Toxicology in vitro : an international journal…
  • 1 June 1994
Isolated and cultured hepatocytes would seem to be an ideal model for the study of hepatic xenobiotic metabolism and metabolism-based hepatotoxicity. However, a serious drawback with this system ofExpand
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Sex- and substrate-dependent effects of the thyroid gland on drug metabolism in the rat.
  • P. Skett, A. Weir
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 15 October 1983
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Pathways of drug metabolism
The routes by which drugs may be metabolised or biotransformed are many and varied and include the chemical reactions of oxidation, reduction, hydrolysis, hydration, conjugation and condensation. ItExpand
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