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4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
We demonstrated previously that TRPV1-dependent regulation of coronary blood flow (CBF) is disrupted in diabetes. Further, we have shown that endothelial TRPV1 is differentially regulated, ultimatelyExpand
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TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: Co-localization at z-discs, costameres and intercalated discs
ABSTRACT Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) and vanilloid subtype-1 (TRPV1) are structurally related, non-selective cation channels that show a high permeabilityExpand
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Propofol Causes Vasodilation In Vivo via TRPA1 Ion Channels: Role of Nitric Oxide and BKCa Channels
Background Transient receptor potential (TRP) ion channels of the A1 (TRPA1) and V1 (TRPV1) subtypes are key regulators of vasomotor tone. Propofol is an intravenous anesthetic known to causeExpand
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Propofol restores TRPV1 sensitivity via a TRPA1-, nitric oxide synthase-dependent activation of PKCε
We previously demonstrated that the intravenous anesthetic, propofol, restores the sensitivity of transient receptor potential vanilloid channel subtype‐1 (TRPV1) receptors via a protein kinase CExpand
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Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents.
Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gasExpand
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TRPA1 ion channel stimulation enhances cardiomyocyte contractile function via a CaMKII-dependent pathway
ABSTRACT Rationale: Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective cation channels that show high permeability to calcium. Previous studies from ourExpand
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TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries
Background Transient receptor potential (TRP) ion channels have emerged as key components contributing to vasoreactivity. Propofol, an anesthetic is associated with adverse side effects includingExpand
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Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation
Significance Endothelial cell migration is required for vessel repair after damage during angioplasty. Migration is inhibited by lipid oxidation products, including lysophosphatidylcholine (lysoPC),Expand
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Modulation of TRPA1 channel activity by Cdk5 in sensory neurons
ABSTRACT Transient receptor potential cation channel, subfamily A, member 1 (TRPA1), is activated by a broad range of noxious stimuli. Cdk5, a member of the Cdk family, has recently been identifiedExpand
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Environmental Aldehyde Sources and the Health Implications of Exposure.
Aldehydes, which are present within the air as well as food and beverage sources, are highly reactive molecules that can be cytotoxic, mutagenic, and carcinogenic. To prevent harm from reactiveExpand
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