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Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.
Several lipid modifications, some of which were attributed to oxidative stress, have been reported in the brains of patients with Alzheimer disease (AD). To evaluate this possibility, allExpand
Regulation of ubiquinone metabolism.
Interest in ubiquinone (UQ) has increased during recent years, mainly because of its antioxidant function and its use as a dietary supplement. However, our knowledge of the biosynthesis, catabolism,Expand
Coenzyme Q– responsive Leigh's encephalopathy in two sisters
A 31‐year‐old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. MuscleExpand
A New Member of the Family of Di-iron Carboxylate Proteins
Ubiquinone (UQ) is an essential cofactor for respiratory metabolism. In yeast, mutation of theCOQ7 gene results in the absence of UQ biosynthesis and demonstrates a role for this gene in the stepExpand
4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures.
Coenzyme Q (Q) is an electron transporter in the respiratory chain and a lipid-soluble antioxidant that decreases in humans with age. Here we show that 4-nitrobenzoate inhibitedExpand
Influence of chronic fluorosis on membrane lipids in rat brain.
Brain membrane lipid in rats were analyzed after being fed either 30 or 100 ppm fluoride for 3, 5, and 7 months. The protein content of brain with fluorosis decreased, whereas the DNA contentExpand
Separation and quantitation of phospholipids and their ether analogues by high-performance liquid chromatography.
The common mobile phase hexane/isopropanol/water used for separation of phospholipids on high-performance liquid chromatography silica columns poses several problems, such as incomplete separationExpand
Correlation of oxidation states of surface chromium species with ethylene polymerization activity for Phillips CrOx/SiO2 catalysts modified by Al-alkyl cocatalyst
Abstract The real oxidation states of active sites on the important industrial Phillips type catalysts are still unclear. In this study, Phillips catalysts calcined at different temperatures (400,Expand
The protective role of plasmalogens in iron-induced lipid peroxidation.
The role of plasmalogens in iron-induced lipid peroxidation was investigated in two liposomal systems. The first consisted of total brain phospholipids with and without plasmalogens, and the secondExpand
Peroxisomal Impairment in Niemann-Pick Type C Disease*
Niemann-Pick type C disease (NPC) belongs to the group of lysosomal storage diseases characterized by an accumulation of cholesterol and sphingomyelin. Using a mutant mouse strain, enzymatic markersExpand