P. Simpson | Semantic Scholar

The choice of cell fate in the epidermis of Drosophila

P. Heitzler, P. Simpson
Biology
Cell
22 March 1991

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila.

P. Heitzler, M. Bourouis, L. Ruel, C. Carteret, P. Simpson
Biology
Development
1996

It is shown that mutation of either the bHLH-encoding genes of the Enhancer of split complex (E(spl)-C) or groucho, like Notch or Delta mutants, cause an overproduction of sensory organ precursors at the expense of epidermis.

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Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila.

M. Haenlin, Y. Cubadda, P. Ramain
Biology
Genes & development
15 November 1997

It is shown that both wild-type Pannier and the dominant mutant form activate transcription from the heterologous alpha globin promoter when transfected into chicken embryonic fibroblasts and the results suggest an antagonistic effect of Ush on Pnr function and reveal a new mode of regulation of GATA factors during development.

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u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila.

Y. Cubadda, P. Heitzler, M. Haenlin
Biology
Genes & development
15 November 1997

A study of the sites at which the dorsocentral bristles arise in mosaic u-shaped nota, suggests that the levels of the u- shaped protein are crucial for the precise positioning of the precursors of these bristles.

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Notch signalling in development: on equivalence groups and asymmetric developmental potential.

P. Simpson
Biology
Current opinion in genetics & development
1 August 1997

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Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila.

P. Simpson
Biology
Development
1 July 1990

Cells in the neurectoderm of Drosophila face a choice between neural and epidermal fates, and the molecular nature of the protein products of the neurogenic genes is consistent with this idea.

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Maternal-Zygotic Gene Interactions during Formation of the Dorsoventral Pattern in Drosophila Embryos.

P. Simpson
Biology
Genetics
1 November 1983

A zygotic action for the dl gene in addition to the maternal effect was revealed by the finding that extra doses of dl(+) in the zygotes can partially rescue the dominant lethality ofheterozygous twi embryos derived from heterozygous dl females at high temperature.

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pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1.

P. Ramain, P. Heitzler, M. Haenlin, P. Simpson
Biology
Development
1 December 1993

Molecular analysis of mutant alleles revealed the presence of two functional domains within the pannier protein: a zinc finger domain showing homology to the GATA-1 family of vertebrate transcription factors and a domain comprising two putative amphipathic helices.

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Parameters of cell competition in the compartments of the wing disc of Drosophila.

P. Simpson
Biology
Developmental biology
1 March 1979

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A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila.

P. Heitzler, M. Haenlin, P. Ramain, M. Calleja, P. Simpson
Biology
Genetics
1 July 1996

A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles.

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