• Publications
  • Influence
Genetic diversity and evolution of hepatitis C virus--15 years on.
  • P. Simmonds
  • Biology, Medicine
  • The Journal of general virology
  • 1 November 2004
Two contrasting aspects of conservatism and adaptability provide a fascinating paradigm in which to explore the complex selection pressures that underlie the evolution of HCV and other persistent viruses. Expand
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
These proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future. Expand
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.
A new nomenclature for HCV variants is proposed in this communication that reflects the two-tiered nature of sequence differences between different viral isolates and describes criteria that would enable new variants to be assigned within the classification as they are discovered. Expand
Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource
This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013. Expand
Human Bocaviruses Are Highly Diverse, Dispersed, Recombination Prone, and Prevalent in Enteric Infections
The high degree of genetic diversity seen among the human bocaviruses found in feces specimens, relative to the highly homogeneous HBoV1, suggest that this worldwide-distributed respiratory pathogen may have recently evolved from an enteric bocvirus after acquiring an expanded tropism favoring the respiratory tract. Expand
Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method
The novel multiplex assay for real-time pan-coronavirus detection enhances respiratory virus diagnosis, overcomes potential diagnostic problems arising through seasonal variation in coronavirus frequency, and provides novel insights into the epidemiology and clinical implications of coronaviruses. Expand
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen
The distribution of antibodies to both a capsid-related recombinant protein and latent antigen of KSHV strongly supports the view that infection with this virus is largely confined to individuals with, or at increased risk for, KS. Expand
Consensus proposals for classification of the family Hepeviridae
This work proposes a taxonomic scheme in which the family Hepeviridae is divided into the genera Orthohepevirus (all mammalian and avian hepatitis E virus (HEV) isolates) and PiscihepeVirus (cutthroat trout virus), and proposals are made for the designation of genotypes within the human and rat HEVs. Expand
The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae
Only GBV-B, a second species within the genus Hepacivirus (type species hepatitis C virus), has been shown to cause hepatitis; it causes acute hepatitis in experimentally infected tamarins. Expand
Epidemiological Profile and Clinical Associations of Human Bocavirus and Other Human Parvoviruses
In the present study, HBoV was a frequently detected, potential respiratory pathogen, with a prevalence and an epidemiological profile comparable to those of RSV. Expand