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Correlates of sleep and waking in Drosophila melanogaster.
Drosophila exhibits a circadian rest-activity cycle, but it is not known whether fly rest constitutes sleep or is mere inactivity. It is shown here that, like mammalian sleep, rest in Drosophila isExpand
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Stress response genes protect against lethal effects of sleep deprivation in Drosophila
Sleep is controlled by two processes: a homeostatic drive that increases during waking and dissipates during sleep, and a circadian pacemaker that controls its timing. Although these two systems canExpand
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Waking Experience Affects Sleep Need in Drosophila
Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecularExpand
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Inducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila
Inducing sleep in flies reverses deficits in long-term memory caused by social enrichment. Sleep is believed to play an important role in memory consolidation. We induced sleep on demand byExpand
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Use-Dependent Plasticity in Clock Neurons Regulates Sleep Need in Drosophila
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleepExpand
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Glutamate, excitotoxicity and amyotrophic lateral sclerosis
The “glutamate hypothesis” is one of three major pathophysiological mechanisms of motor neurone injury towards which current research effort into amyotrophic lateral sclerosis (ALS) is directed.Expand
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Essentials of sleep recordings in Drosophila: moving beyond sleep time.
The power of Drosophila genetics can be used to facilitate the molecular dissection of sleep regulatory mechanisms. While evaluating total sleep time and homeostatic processes provides valuableExpand
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How deeply does your mutant sleep? Probing arousal to better understand sleep defects in Drosophila
The fruitfly, Drosophila melanogaster, has become a critical model system for investigating sleep functions. Most studies use duration of inactivity to measure sleep. However, a defining criterionExpand
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D1 Receptor Activation in the Mushroom Bodies Rescues Sleep-Loss-Induced Learning Impairments in Drosophila
BACKGROUND Extended wakefulness disrupts acquisition of short-term memories in mammals. However, the underlying molecular mechanisms triggered by extended waking and restored by sleep are unknown.Expand
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The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis and Prevents Learning Impairments Following Sleep Loss
Starvation, which is common in the wild, appears to initiate a genetic program that allows fruitflies to remain awake without the sleepiness and cognitive impairments that typically follow sleepExpand
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