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Transvascular delivery of small interfering RNA to the central nervous system
TLDR
RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier and afforded robust protection against fatal viral encephalitis in mice. Expand
RNA interference targeting Fas protects mice from fulminant hepatitis
TLDR
In a more fulminant hepatitis induced by injecting agonistic Fas-specific antibody, 82% of mice treated with siRNA that effectively silenced Fas survived for 10 days of observation, whereas all control mice died within 3 days. Expand
siRNA-directed inhibition of HIV-1 infection
TLDR
It is reported that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein. Expand
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
TLDR
The potential for systemic, cell-type specific, antibody-mediated siRNA delivery to HIV-infected or envelope-transfected cells is demonstrated and an ErbB2 single-chain antibody fused with protamine delivered siRNAs specifically into ErBB2-expressing cancer cells. Expand
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.
TLDR
The results suggest that effector differentiation is not a prerequisite for memory cell generation, and T-GFP mice provide a simple means to generate memory cells in virtually unlimited numbers. Expand
miRNA Profiling of Naïve, Effector and Memory CD8 T Cells
TLDR
The results suggest that dynamic changes in the expression of miRNAs may be important for the regulation of gene expression during antigen-induced T cell differentiation and suggests possible novel mechanisms for miRNA biogenesis and function. Expand
T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice
TLDR
SiRNA therapy for HIV infection appears to be feasible in a preclinical animal model and could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Expand
Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.
TLDR
The results suggest that the chance to eradicate an infection by T-cell-mediated lysis may be undermined once an infection becomes chronic, and impaired antiviral cytotoxicity during chronic infection likely represents the immune response to chronic antigenic exposure. Expand
A Single siRNA Suppresses Fatal Encephalitis Induced by Two Different Flaviviruses
TLDR
RNAi-based intervention affords near complete protection from both JEV- and WNV- induced encephalitis in mice, and shows that siRNA can be used as a broad-spectrum antiviral agent for treating enphalitis caused by multiple related viruses. Expand
Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.
TLDR
It is suggested that a significant proportion of HIV-specific CD8 T cells may be functionally compromised in vivo and that some function can be restored by exposure to IL-2. Expand
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