• Publications
  • Influence
Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals
  • P. Setlow
  • Biology, Medicine
  • Journal of applied microbiology
  • 1 September 2006
A number of mechanisms are responsible for the resistance of spores of Bacillus species to heat, radiation and chemicals and for spore killing by these agents. Spore resistance to wet heat isExpand
Resistance of Bacillus Endospores to Extreme Terrestrial and Extraterrestrial Environments
The molecular laboratory model of spore resistance mechanisms is summarized and attempts to use the model as a basis for exploration of the resistance of spores to environmental extremes both on Earth and during postulated interplanetary transfer through space as a result of natural impact processes. Expand
Spore germination.
  • P. Setlow
  • Medicine
  • Current opinion in microbiology
  • 2003
The germination of dormant spores of Bacillus species is the first crucial step in the return of spores to vegetative growth, and is induced by nutrients and a variety of non-nutrient agents.Expand
I will survive: DNA protection in bacterial spores.
  • P. Setlow
  • Biology, Medicine
  • Trends in microbiology
  • 1 April 2007
Dormant spores of Bacillus, Clostridium and related species can survive for years, largely because spore DNA is well protected against damage by many different agents. This DNA protection is partly aExpand
Germination of Spores of Bacillus Species: What We Know and Do Not Know
  • P. Setlow
  • Biology, Medicine
  • Journal of bacteriology
  • 31 January 2014
ABSTRACT Spores of Bacillus species can remain in their dormant and resistant states for years, but exposure to agents such as specific nutrients can cause spores' return to life within minutes inExpand
Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors
It is demonstrated that a ygaG mutant has the perR phenotype: it is highly resistant to peroxides and overexpresses catalase, alkyl hydroperoxide reductase and the DNA binding protein MrgA, and it encodes the peroxide regulon repressor and is allelic with perR. Expand
Genetic Requirements for Induction of Germination of Spores of Bacillus subtilis by Ca2+-Dipicolinate
It is found that Ca(2+)-DPA triggers germination by first activating CwlJ-dependent cortex hydrolysis; this mechanism is different from nutrient-induced germination where cortex Hydrolysis is not required for the early germination events in the spore core. Expand
Role of Ger Proteins in Nutrient and Nonnutrient Triggering of Spore Germination in Bacillus subtilis
Characterizing spore germination in a mutant strain that contained deletions at all known gerA-like loci showed that proteins encoded by gerA family members are required for nutrient-induced germination but not for chemical-triggered germination, supporting the hypothesis that the GerA family encodes receptors for nutrient germinants. Expand
Germination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved.
In this review, the roles of components of the spore germination machinery of C. perfringens and several Bacillus species and the bioinformatic analysis of germination proteins in the Bacillales and Clostridiales orders are discussed and models for the germination of spores of these two orders are proposed. Expand
The forespore line of gene expression in Bacillus subtilis.
An integrated overview of the entire program of sporulation gene expression is presented, which is governed by the RNA polymerase sigma factors sigma(F) andSigma(G) and the DNA-binding proteins RsfA and SpoVT and the ykoV gene product, a homolog of the non-homologous end-joining protein Ku, is shown to associate with the nucleoid during germination. Expand