High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma.
High-dose therapy with autologous stem-cell rescue is an effective first-line treatment for patients with multiple myeloma who are younger than 65 years of age and trend toward a greater survival benefit in the group of patients with a poor prognosis.
Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade
It is shown, in a window-of-opportunity clinical study, that intravenous infusion of oncolytic human Orthoreovirus leads to infection of tumor cells subsequently resected as part of standard clinical care, both in high-grade glioma and in brain metastases, and increases cytotoxic T cell tumor infiltration relative to patients not treated with virus.
Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction
Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen.
VEGF expression was significantly correlated with estrogen receptor status and inversely correlated with tumor grade and MVD correlation with tumor size, and circulating VEGF did not correlate with any clinicopathological factor, including MVD or V EGF expression.
Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.
No significant differences were seen between VHL subgroups with regard to clinicopathologic features including stage, grade, tumor size, cancer-free and overall survival, with the exception of a significant association between loss of heterozygosity and grade, although a possible trend for survival differences based on mutation location was apparent.
Measles virus causes immunogenic cell death in human melanoma
It is demonstrated that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.
Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction.
- S. Burchill, M. Bradbury, K. Pittman, J. Southgate, B. Smith, P. Selby
- Biology, MedicineBritish Journal of Cancer
- 1 February 1995
It is found that reverse transcriptase (RT)-PRC for tissue-specific gene expression is a useful technique for identifying small numbers of circulating cells in melanoma and neuroblastoma patients and suggests a role for RT-PCR in the detection of colon carcinoma metastasis in blood and bone marrow.
Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.
Topo1 immunohistochemistry identified subpopulations that did or did not benefit from irinotecan, and possibly also from oxaliplatin, and if verified independently, this information will contribute to the individualization of treatment for colorectal cancer.
Proteomic analysis of melanoma‐derived exosomes by two‐dimensional polyacrylamide gel electrophoresis and mass spectrometry
This study presents a starting point for future more in‐depth protein studies of tumour‐derived exosomes which will aid the understanding of their biogenesis and targeting for use in anti‐tumour immunotherapy protocols.