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Purification and Characterization of an Extracellular Protease from the Fish Pathogen Yersinia ruckeri and Effect of Culture Conditions on Production
TLDR
A novel protease, hydrolyzing azocasein, was identified, purified, and characterized from the culture supernatant of the fish pathogenYersinia ruckeri and showed characteristics of a cold-adapted protein.
A Mutation in Flavobacterium psychrophilum tlpB Inhibits Gliding Motility and Induces Biofilm Formation
TLDR
Quantitative analysis of the thiol groups of periplasmic proteins revealed that TLPB is required for reduction of these groups, which appear to be antagonistic properties, which are both affected by TlpB.
Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number
TLDR
Findings suggest an involvement of FAK in the onset and progression of HNSCC and provide an insight into a mechanism ofFAK activation alternative to gene amplification.
Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells
TLDR
Using epidermis-specific Itga3 KO mice subjected to the 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate two-stage skin carcinogenesis protocol, it is demonstrated that efficient tumor development is critically dependent on the presence of α3β1.
Purification and Characterization of a Psychrophilic, Calcium-Induced, Growth-Phase-Dependent Metalloprotease from the Fish Pathogen Flavobacterium psychrophilum
TLDR
It is found that production of Fpp1 depends on factors such as calcium concentration, growth phase of the culture, and temperature, and the combination of these parameters corresponds to the combination in the natural host during outbreaks of disease caused by F. psychrophilum.
Development of Genetic Techniques for the Psychrotrophic Fish Pathogen Flavobacterium psychrophilum
TLDR
The development of techniques for the genetic manipulation of F. psychrophilum and the identification of plasmids, selectable markers, a reporter system, and a transposon that function in several isolates of this fish pathogen are described.
In Vitro and In Vivo Studies of the Yrp1 Protease from Yersinia ruckeri and Its Role in Protective Immunity against Enteric Red Mouth Disease of Salmonids
TLDR
The hydrolytic and immunogenic properties of Yrp1 are described, which opens a vast field of study not only with regard to fish disease progression but also in pathogen interactions, temporal gene expression, carrier stages, antibiotic resistance selection, etc.
Isolation and analysis of a protease gene with an ABC transport system in the fish pathogen Yersinia ruckeri: insertional mutagenesis and involvement in virulence.
TLDR
The mutant strains lacked protease activity as well as the Yrp1 protein and, although physiologically similar to the parental strain when growing on nutrient broth medium, they were attenuated in virulence when bacteria were injected intraperitoneally into rainbow trout (Oncorhynchus mykiss).
Integrin alpha6 maintains the structural integrity of the kidney collecting system.
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