P. Seale

Publications98
h-index47
Citations17,516
Highly Influential Citations1,096
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Pax7 Is Required for the Specification of Myogenic Satellite Cells
The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization… Expand
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Brown and beige fat: development, function and therapeutic potential
Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown adipocytes are located… Expand
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PRDM16 controls a brown fat/skeletal muscle switch
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells… Expand
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Transcriptional control of brown fat determination by PRDM16.
Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger protein… Expand
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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, while… Expand
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Myogenic specification of side population cells in skeletal muscle
Skeletal muscle contains myogenic progenitors called satellite cells and muscle-derived stem cells that have been suggested to be pluripotent. We further investigated the differentiation potential of… Expand
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Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis
We assessed viable Pax7 − / − mice in 129Sv/J background and observed reduced growth and marked muscle wasting together with a complete absence of functional satellite cells. Acute injury resulted in… Expand
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Transcriptional Control of Preadipocyte Determination by Zfp423
The worldwide epidemic of obesity has increased the urgency to develop a deeper understanding of physiological systems related to energy balance and energy storage, including the mechanisms… Expand
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Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
Obesity is an increasingly prevalent disease regulated by genetic and environmental factors. Emerging studies indicate that immune cells, including monocytes, granulocytes and lymphocytes, regulate… Expand
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Wnt Signaling Induces the Myogenic Specification of Resident CD45+ Adult Stem Cells during Muscle Regeneration
The observation that CD45(+) stem cells injected into the circulation participate in muscle regeneration raised the question of whether CD45(+) stem cells resident in muscle play a physiological role… Expand
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