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Fast folding and comparison of RNA secondary structures
- I. Hofacker, W. Fontana, P. Stadler, L. S. Bonhoeffer, M. Tacker, P. Schuster
- Chemistry, Computer Science
- 1 February 1994
An efficient heuristic for the inverse folding problem of RNA is introduced. Expand
Continuity in evolution: on the nature of transitions.
To distinguish continuous from discontinuous evolutionary change, a relation of nearness between phenotypes is needed. Such a relation is based on the probability of one phenotype being accessible… Expand
The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.
This paper is the first part of a trilogy, which comprises a detailed study of a special type of functional organization and demonstrates its relevance with respect to the origin and evolution of… Expand
Self-replication with errors. A model for polynucleotide replication.
A model for polynucleotide replication is presented and analyzed by means of perturbation theory. Two basic assumptions allow handling of sequences up to a chain length of v approximately 80… Expand
Generic properties of combinatory maps: neutral networks of RNA secondary structures.
Random graph theory is used to model and analyse the relationships between sequences and secondary structures of RNA molecules, which are understood as mappings from sequence space into shape space.… Expand
Combinatorics of RNA Secondary Structures
- I. Hofacker, P. Schuster, P. Stadler
- Mathematics, Computer Science
- Discret. Appl. Math.
- 9 November 1998
We construct recursion formulae enumerating various sub-classes of these graphs as well as certain structural elements (sub-graphs). Expand
Error thresholds of replication in finite populations mutation frequencies and the onset of Muller's ratchet.
The occurrence of thresholds for error propagation in asexually replicating populations is investigated by means of a simple birth and death model as well as by numerical simulation. Previous results… Expand
Physics Beyond Colliders at CERN: Beyond the Standard Model Working Group Report
The Physics Beyond Colliders initiative is an exploratory study aimed at exploiting the full scientific potential of the CERN's accelerator complex and scientific infrastructures through projects… Expand
Stationary mutant distributions and evolutionary optimization.
Molecular evolution is modelled by erroneous replication of binary sequences. We show how the selection of two species of equal or almost equal selective value is influenced by its nearest neighbours… Expand
A note on evolutionary stable strategies and game dynamics.
- J. Hofbauer, P. Schuster, K. Sigmund
- Computer Science, Medicine
- Journal of theoretical biology
- 7 December 1979
In 1974 J. Maynard Smith introduced the fundamental notion of an evolutionarily stable strategy (ESS) in order to explain the evolution of genetically determined social behaviour within a single animal species. Expand