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Assessment of the daily blood pressure load as a determinant of cardiac function in patients with mild-to-moderate hypertension.
Data show that the percentage of elevated BP values that includes both the awake and asleep periods is predictive of cardiac target organ involvement in patients with mild-to-moderate hypertension. Expand
Average daily blood pressure, not office blood pressure, determines cardiac function in patients with hypertension.
The findings demonstrate that patients with blood pressure elevation only in the physician's office have cardiac size and function similar to those of normotensive individuals, and the average daily blood pressure best predicts cardiac end-organ damage. Expand
Stroke, Major Bleeding, and Mortality Outcomes in Warfarin Users With Atrial Fibrillation and Chronic Kidney Disease: A Meta-Analysis of Observational Studies.
Based on this meta-analysis, the use of warfarin for AF may have an unfavorable risk/benefit ratio in patients with end-stage CKD but not in those with non-end- stage CKD. Expand
A Pharmacokinetic and Pharmacodynamic Study of Intravenous Pilocarpine in Humans
The pharmacokinetic linearity of the system and proportionality between the area under plasma concentration-time curves and overall salivary response have important implications for the design and utilization of pilocarpine dosage forms. Expand
Cardiovascular effects of the thiazolidinediones
Evidence is described that thiazolidinediones have beneficial effects on the cardiovascular system independent of their antidiabetic effect, and they may provide a novel method for the prevention and treatment of cardiovascular diseases. Expand
Occurrence of Antibodies to Borrelia burgdorferi in Patients with Nonspirochetal Subacute Bacterial Endocarditis
The frequency and specificity of antibodies to B. burgdorferi (as measured by ELISA) in patients with endocarditis were studied, and positive immunoblots were interpreted to be diagnostic of Lyme disease according to published criteria. Expand
Congenital unilateral hydrocephalus--CT findings.
Following ventriculo-peritoneal shunt, the babies had a normal cognitive neurodevelopment and the role of cranial computed tomography (CT) in diagnosis and follow-up is emphasized. Expand
Rapid ventricular filling in left ventricular hypertrophy: II. Pathologic hypertrophy.
To define the extent of left ventricular ejection and filling abnormalities in patients with mild hypertension, a non-imaging nuclear probe was used to generate high resolution time-activity curvesExpand
Regression of left ventricular mass is accompanied by improvement in rapid left ventricular filling following antihypertensive therapy with metoprolol.
Left ventricular hypertrophy is associated with abnormal left ventricular diastolic filling in patients with hypertension. To assess the effects of antihypertensive therapy on the heart in nineExpand
Effects of age and 24-hour ambulatory blood pressure on rapid left ventricular filling.
It is demonstrated that LV filling rate is more dependent upon age and BP than left atrial or LV size, which negated the significance of the relation of these 2 cardiac structural variables with LV fill rate. Expand