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Inhibition of death receptor signals by cellular FLIP
TLDR
The characterization of an inhibitor of apoptosis is reported, designated FLIP (for FLICE-inhibitory protein), which is predominantly expressed in muscle and lymphoid tissues and may be implicated in tissue homeostasis as an important regulator of apoptotic regulation. Expand
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
TLDR
F Fas kills activated primary T cells efficiently in the absence of active caspases, which results in necrotic morphological changes and late mitochondrial damage but no cytochrome c release. Expand
Cracking the BAFF code
TLDR
The possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell tolerance is considered. Expand
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
TLDR
BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival and is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAff-deficient mice. Expand
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
TLDR
It is shown that apoptosis caused by an IAC is blocked by the caspase 8 inhibitor crmA and that IAP antagonists activate NF-kappaB signaling via inhibtion of cIAP1, suggesting novel uses of these compounds in treating cancer. Expand
BAFF AND APRIL: a tutorial on B cell survival.
TLDR
The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells. Expand
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
TLDR
A new family of viral inhibitors (v-FLIPs) which interfere with apoptosis signalled through death receptors3 and which are present in several γ-herpesviruses (including Kaposi's-sarcoma-associated human herpesvirus-8), as well as in the tumorigenic human molluscipoxvirus4. Expand
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
TLDR
A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function. Expand
Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations
TLDR
Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys. Expand
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
TLDR
Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro and indicated that IVIG may be an effective treatment for toxic epidermal necrolysis of TEN. Expand
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