Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures.
- R. Venkataramanan, V. Ramachandran, B. Komoroski, S. Zhang, P. Schiff, S. Strom
- Biology, MedicineDrug metabolism and disposition: the biological…
- 1 November 2000
Observations point to the potential of silymarin to impair hepatic metabolism of certain coadministered drugs in humans and may result in increased toxicity of certain drugs.
Ergot and its alkaloids.
- P. Schiff
- MedicineAmerican Journal of Pharmaceutical Education
- 15 October 2006
The history and pharmacognosy of ergot is reviewed, and the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives are described.
Opium and Its Alkaloids
- P. Schiff
The history and pharmacognosy of opium is reviewed, and the chemistry, pharmacology, and therapeutic uses of the major opium alkaloids are described.
- P. Schiff
- ChemistryJournal of Natural Products
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids
- S. J. Marshall, P. F. Russell, P. Schiff
- Chemistry, BiologyAntimicrobial Agents and Chemotherapy
- 1 January 1994
None of the 24 bisbenzylisoquinoline alkaloids exhibited significant cytotoxicity against the KB cell line, the most toxic being berbamine, with an IC50 of 17.8 microM (theIC50 of podophyllotoxin was 0.008 microM).
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.
Twenty-one alkaloids have been assessed for activities against Plasmodium falciparum (multidrug- resistant strain K1) in vitro; 18 of these are reported for the first time and are discussed in the context of structure-activity relationships.
In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against eishmania donovani and Trypanosoma brucei brucei
- M. Camacho, J. Phillipson, S. Croft, P. Rock, S. J. Marshall, P. Schiff
- Chemistry, BiologyPhytotherapy Research
- 1 August 2002
In the search for antiprotozoal compounds from natural sources, Triclisia patens displayed activity against L. donovani promastigotes (IC50 = 1.5 μg/mL) and T. b. brucei blood stream trypomastigote…
Chemical constituents of Curatella americana (Dilleniaceae).
- M. El-Azizi, A. Ateya, G. H. Svoboda, P. Schiff, D. Slatkin, J. Knapp
- BiologyJournal of pharmaceutical sciences
- 1 March 1980
A phytochemical investigation of an ethanolic extract of the leaves of Curatella americana Linn. (Dilleniaceae) resulted in the isolation and identification of the flavonol glycoside avicularin and…
Chemical constituents of Cannabis sativa L. root.
- D. Slatkin, N. Doorenbos, L. Harris, A. N. Masoud, M. W. Quimby, P. Schiff
- ChemistryJournal of Pharmacy and Science
- 1 December 1971
An extract of Cannabis sativa L. root yielded two pentacyclic triterpenes, friedelin and epifriedelanol, and N-(p-hydroxy-β-phenylethyl)-p-Hydroxy-trans-cinnamamide, which was confirmed by synthesis and comparison to authentic friedelin.
Anhydrocannabisativine, a new alkaloid from Cannabis sativa L.
- M. Elsohly, C. Turner, C. Phoebe, J. Knapp, P. Schiff, D. Slatkin
- ChemistryJournal of pharmaceutical sciences
Ethanol extracts of the leaves and roots of a Mexican variant of Cannabis sativa L. (marijuana) afforded the new spermidine alkaloid, anhydrocannabisativine, which was determined by spectral analysis and semisynthesis.