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Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures.
Observations point to the potential of silymarin to impair hepatic metabolism of certain coadministered drugs in humans and may result in increased toxicity of certain drugs. Expand
Ergot and its alkaloids.
  • P. Schiff
  • Medicine
  • American journal of pharmaceutical education
  • 15 October 2006
The history and pharmacognosy of ergot is reviewed, and the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives are described. Expand
Bisbenzylisoquinoline alkaloids.
  • P. Schiff
  • Medicine
  • Journal of natural products
  • 1987
Opium and Its Alkaloids
PROLOGUE This manuscript reviews the history and pharmacognosy of opium, and describes the chemistry, pharmacology, and therapeutic uses of the major opium alkaloids. An abbreviated form of theExpand
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.
Twenty-one alkaloids have been assessed for activities against Plasmodium falciparum (multidrug- resistant strain K1) in vitro; 18 of these are reported for the first time and are discussed in the context of structure-activity relationships. Expand
In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids
None of the 24 bisbenzylisoquinoline alkaloids exhibited significant cytotoxicity against the KB cell line, the most toxic being berbamine, with an IC50 of 17.8 microM (theIC50 of podophyllotoxin was 0.008 microM). Expand
In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against eishmania donovani and Trypanosoma brucei brucei
In the search for antiprotozoal compounds from natural sources, Triclisia patens displayed activity against L. donovani promastigotes (IC50 = 1.5 μg/mL) and T. b. brucei blood stream trypomastigoteExpand
Chemical constituents of Curatella americana (Dilleniaceae).
A phytochemical investigation of an ethanolic extract of the leaves of Curatella americana Linn. (Dilleniaceae) resulted in the isolation and identification of the flavonol glycoside avicularin andExpand
Quaternary alkaloids of Thalictrum foliolosum
Abstract The isolation and identification of eleven alkaloids from the quaternary alkaloid fraction of a root extract of Thalictrum foliolosum are described
Anhydrocannabisativine, a new alkaloid from Cannabis sativa L.
Ethanol extracts of the leaves and roots of a Mexican variant of Cannabis sativa L. (marijuana) afforded the new spermidine alkaloid, anhydrocannabisativine, which was determined by spectral analysis and semisynthesis. Expand