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- Publications
- Influence
Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons
- P. Scheiffele, J. Fan, J. Choih, R. Fetter, Tito A. Serafini
- Biology, Medicine
- Cell
- 9 June 2000
Most neurons form synapses exclusively with other neurons, but little is known about the molecular mechanisms mediating synaptogenesis in the central nervous system. Using an in vitro system, we… Expand
Control of Excitatory and Inhibitory Synapse Formation by Neuroligins
- Ben Chih, H. Engelman, P. Scheiffele
- Biology, Medicine
- Science
- 25 February 2005
The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between… Expand
Neurexin mediates the assembly of presynaptic terminals
- C. Dean, F. Scholl, +4 authors P. Scheiffele
- Biology, Medicine
- Nature Neuroscience
- 1 July 2003
Neurexins are a large family of proteins that act as neuronal cell-surface receptors. The function and localization of the various neurexins, however, have not yet been clarified. Beta-neurexins are… Expand
Alternative Splicing Controls Selective Trans-Synaptic Interactions of the Neuroligin-Neurexin Complex
- Ben Chih, L. Gollan, P. Scheiffele
- Chemistry, Medicine
- Neuron
- 20 July 2006
Formation of synapses requires specific cellular interactions that organize pre- and postsynaptic compartments. The neuroligin-neurexin complex mediates heterophilic adhesion and can trigger assembly… Expand
Disorder-associated mutations lead to functional inactivation of neuroligins.
- Ben Chih, Shehla Khan Afridi, L. Clark, P. Scheiffele
- Biology, Medicine
- Human molecular genetics
- 15 July 2004
Autism is a neuro-developmental syndrome that affects 0.1-0.5% of the population. It has been proposed that alterations in neuronal circuitry and/or neuronal signaling are responsible for the… Expand
Cell-cell signaling during synapse formation in the CNS.
- P. Scheiffele
- Biology, Medicine
- Annual review of neuroscience
- 28 November 2003
Synapses join individual nerve cells into a functional network. Specific cell-cell signaling events regulate synapse formation during development and thereby generate a highly reproducible… Expand
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin
- K. Futai, M. J. Kim, T. Hashikawa, P. Scheiffele, M. Sheng, Y. Hayashi
- Chemistry, Medicine
- Nature Neuroscience
- 1 February 2007
The structure and function of presynaptic and postsynaptic components of the synapse are highly coordinated. How such coordination is achieved and the molecules involved in this process have not been… Expand
Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism
- Stéphane J Baudouin, Julien Gaudias, +9 authors P. Scheiffele
- Biology, Medicine
- Science
- 5 October 2012
Reversing Autism in Mice Autism comprises a heterogeneous group of neurodevelopmental disorders characterized by defects in communication and social inter action. A group of nonsyndromic forms of… Expand
SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1
- T. Iijima, Karen Wu, +4 authors P. Scheiffele
- Biology, Medicine
- Cell
- 23 December 2011
The assembly of synapses and neuronal circuits relies on an array of molecular recognition events and their modification by neuronal activity. Neurexins are a highly polymorphic family of synaptic… Expand
Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling
- E. C. Budreck, O.-B. Kwon, +9 authors J. Kim
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 26 December 2012
Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly… Expand