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Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons
Most neurons form synapses exclusively with other neurons, but little is known about the molecular mechanisms mediating synaptogenesis in the central nervous system. Using an in vitro system, weExpand
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Control of Excitatory and Inhibitory Synapse Formation by Neuroligins
The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling betweenExpand
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Neurexin mediates the assembly of presynaptic terminals
Neurexins are a large family of proteins that act as neuronal cell-surface receptors. The function and localization of the various neurexins, however, have not yet been clarified. Beta-neurexins areExpand
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Alternative Splicing Controls Selective Trans-Synaptic Interactions of the Neuroligin-Neurexin Complex
Formation of synapses requires specific cellular interactions that organize pre- and postsynaptic compartments. The neuroligin-neurexin complex mediates heterophilic adhesion and can trigger assemblyExpand
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Disorder-associated mutations lead to functional inactivation of neuroligins.
Autism is a neuro-developmental syndrome that affects 0.1-0.5% of the population. It has been proposed that alterations in neuronal circuitry and/or neuronal signaling are responsible for theExpand
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Cell-cell signaling during synapse formation in the CNS.
  • P. Scheiffele
  • Biology, Medicine
  • Annual review of neuroscience
  • 28 November 2003
Synapses join individual nerve cells into a functional network. Specific cell-cell signaling events regulate synapse formation during development and thereby generate a highly reproducibleExpand
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Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin
The structure and function of presynaptic and postsynaptic components of the synapse are highly coordinated. How such coordination is achieved and the molecules involved in this process have not beenExpand
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Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism
Reversing Autism in Mice Autism comprises a heterogeneous group of neurodevelopmental disorders characterized by defects in communication and social inter action. A group of nonsyndromic forms ofExpand
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SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1
The assembly of synapses and neuronal circuits relies on an array of molecular recognition events and their modification by neuronal activity. Neurexins are a highly polymorphic family of synapticExpand
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Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling
Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorlyExpand
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