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A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies.
- Christine E Schaner, G. Deshpande, P. Schedl, W. G. Kelly
- Biology, Medicine
- Developmental cell
- 1 November 2003
Results indicate that genome-wide repression via a nanos-regulated, germ cell-specific chromatin organization is a conserved feature of germline maintenance during embryogenesis. Expand
A position-effect assay for boundaries of higher order chromosomal domains
This work has tested whether two putative domain boundaries, scs and scs', from the Drosophila 87A7 heat shock locus can establish a domain of independent gene activity in vivo and insulate against chromosomal position effects. Expand
The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.
Analysis of the effect of orb mutants on the distribution of RNAs known to be required for oocyte differentiation and polarity and phenotypic characterization of the orb mutants indicates that orb functions in RNA localization at multiple points during oogenesis. Expand
Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless
Results suggest that wingless regulates accumulation of arm protein by a posttranscriptional mechanism and it is shown that arm protein is closely associated with the plasma membrane in virtually all cell types and often colocalizes with F-actin. Expand
The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain.
Fab-8 together with the previously identified Fab-7 boundary delimit the first genetically defined higher order domain in a multicellular eukaryote, and it is demonstrated that the insulating activity of the Fab-8 boundary in BX-C is absolutely essential for the proper specification of parasegmental identity by the iab-7 andiab-8 cis-regulatory domains. Expand
The primary sex determination signal of Drosophila acts at the level of transcription
A two-step model for the initial activation of Sxl in females is suggested, in which a special class of SXl mRNAs is expressed in female embryos from an early promoter that responds to the genes signaling the X:A ratio. Expand
The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains.
The sequence and chromatin organization of the DNA segments surrounding the two hsp 70 genes at the Drosophila melanogaster cytogenetic locus 87A7 are examined, indicating that this heat shock locus is flanked on both the proximal and distal sides by novel chromatin structures, which are called scs and scs' (specialized Chromatin structures). Expand
Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex.
The model that Fab-7 functions as a domain boundary within the context of the bithorax complex, makingFab-7 one of the first boundary elements that is known to have an essential function in vivo. Expand
The locus of
Two of seven c-myc-transfected Abelson lines assemble VA genes while growing in culture suggesting that RS recombination is functionally correlated with the activation of the Igx, locus. Expand
The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction.
SBP (scs binding protein), a component of the scs nucleoprotein complex, is identified and characterization and it is shown that SBP is encoded by the zeste-white 5 gene and that mutations inZeste- white 5 reduce the enhancer-blocking activity of the multimerized oligonucleotides. Expand