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Implementation of Multi-Curie Production of 99mTc by Conventional Medical Cyclotrons
The direct production of 99mTc via proton bombardment of 100Mo can be practically achieved in high yields using conventional medical cyclotrons, which eliminates the need for enriched uranium and the radioactive waste associated with the processing of uranium targets.
Manganese-52 positron emission tomography tracer characterization and initial results in phantoms and in vivo.
Mn is a promising tracer for small animal PET imaging, yielding image quality comparable to (18)F and potential applications include studies similar to Mn-enhanced neuronal MRI, and in other organ systems including bones, spinal cord, and the digestive tract.
Thiol- and thioether-based bifunctional chelates for the {M(CO)3}+ core (M = Tc, Re).
By analogy to the recently described single amino acid chelate (SAAC) technology for complexation of the {M(CO)3}+ core (M = Tc, Re), a series of tridentate ligands containing thiolate and thioether
PBB3 imaging in Parkinsonian disorders: Evidence for binding to tau and other proteins
To study selective regional binding for tau pathology in vivo, using PET with [11C]PBB3 in PSP patients, and other conditions not typically associated with tauopathy.
3D printed plastics for beam modulation in proton therapy.
Two 3D printing methods, fused filament fabrication (FFF) and PolyJet™ (PJ) were investigated for suitability in clinical proton therapy (PT) energy modulation and both were found to print significant, sporadic defects associated with sharp edges on the order of 0.2 mm.
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
A mechanism by which oncogenic RAS preserves intracellular redox balance is uncovers and an unexpected role for xCT is identified in supporting RAS-induced transformation and tumorigenicity is identified.