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Microtubule Minus-End Binding Protein CAMSAP2 Controls Axon Specification and Dendrite Development
In neurons, most microtubules are not associated with a central microtubule-organizing center (MTOC), and therefore, both the minus and plus-ends of these non-centrosomal microtubules are foundExpand
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Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation
In cultured vertebrate neurons, axons have a uniform arrangement of microtubules with plus-ends distal to the cell body (plus-end-out), whereas dendrites contain mixed polarity orientations with bothExpand
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Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture.
Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites. However, the spatial coordination betweenExpand
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Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport
Summary Endocytosis of amyloid-&bgr; precursor protein (APP) is thought to represent the major source of substrate for the production of the amyloidogenic A&bgr; peptide by the &bgr;-secretase BACE1.Expand
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Molecular characterization of a trafficking organelle: Dissecting the axonal paths of calsyntenin‐1 transport vesicles
Kinesin motors play crucial roles in the delivery of membranous cargo to its destination and thus for the establishment and maintenance of cellular polarization. Recently, calsyntenin‐1 wasExpand
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Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines
Compartmentalization of calcium-dependent plasticity allows for rapid actin remodeling in dendritic spines. However, molecular mechanisms for the spatio-temporal regulation of filamentous actinExpand
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Interaction of Syntenin-1 and the NG2 Proteoglycan in Migratory Oligodendrocyte Precursor Cells*
Migration of oligodendrocyte precursors along axons is a necessary prerequisite for myelination, but little is known about underlying mechanisms. NG2 is a large membrane proteoglycan implicated inExpand
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The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development
Summary Neuron morphology and function are highly dependent on proper organization of the cytoskeleton. In neurons, the centrosome is inactivated early in development, and acentrosomal microtubulesExpand
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Automated quantification of synapses by fluorescence microscopy
The quantification of synapses in neuronal cultures is essential in studies of the molecular mechanisms underlying synaptogenesis and synaptic plasticity. Conventional counting of synapses based onExpand
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Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans.
The serine peptidase neurotrypsin is stored in presynaptic nerve endings and secreted in an inactive zymogenic form by synaptic activity. After activation, which requires activity of postsynapticExpand
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