P. Sawyer

Publications32
h-index13
Citations943
Highly Influential Citations7
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Miconazole: A Review of its Antifungal Activity and Therapeutic Efficacy
TLDR
Preliminary experience with oral and intravenous miconazole therapy in systemic candidiasis is promising, and the vaginal cream has produced higher cure rates than conventional nystatin vaginal tablets or amphotericin B vaginal cream, and there have been no published comparisons with other antifungal agents.
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Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.
TLDR
The majority of patients tolerate fenfluramine satisfactorily, although some patients may have to discontinue the drug because of troublesome gastro-intestinal problems, diarrhoea, drowsiness or dizziness, and it probably has little abuse potential.
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Metoclopramide: A Review of its Pharmacological Properties and Clinical Use
TLDR
Pharmacodynamic studies in man and in a variety of experimental animals have established that metoclopramide, after oral or intravenous administration, rapidly affects the motility of the gastro-intestinal tract, and is effective in preventing apomorphine-induced vomiting in man.
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Carbenoxolone: A Review of its Pharmacological Properties and Therapeutic Efficacy in Peptic Ulcer Disease
TLDR
Carbenoxolone is of greatest benefit in accelerating the healing of gastric ulcers in patients for whom hospitalisation is not possible or desirable, but it should only be used in the ambulatory patient when careful and regular observation of serum electrolytes, blood pressure and weight is possible and when it is known that the patient will attend regular follow-up.
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Tobramycin: A Review of its Antibacterial and Pharmacokinetic Properties and Therapeutic Use
TLDR
Tobramycin is a new aminoglycoside antibiotic with a broad antibacterial spectrum in vitro, and pharmacokinetic properties similar to those for gentamicin, and appears to offer no clear advantages over gentamicIn against sensitive organisms it is indicated in infection caused by strains of P. aeruginosa.
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Clotrimazole: A Review of its Antifungal Activity and Therapeutic Efficacy
TLDR
Clotrimazole2, a synthetic imidazole derivative, is primarily used locally in the treatment of vaginal and skin infections due to yeasts and dermatophytes and has been successful in patients who had failed to respond to other antifungal agents such as nystatin and amphotericin B.
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Postprandial alterations in hemodynamics and blood pressure in normal subjects.
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Beclomethasone Dipropionate: II: Allergic Rhinitis and Other Conditions
TLDR
Intranasal beclomethasone dipropionate is useful in controlling symptoms persisting after polypectomy and may possibly delay or eliminate the need for the surgical removal of nasal polyps, which may shrink after several weeks or months of treatment.
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Massive Transfusion in Adults:Diagnoses, Survival and Blood Bank Support
TLDR
In a retrospective study covering a 2‐year period (1986–1987), 125 patients received massive blood transfusion, survival rates ranged from 38% for patients with hepatic failure to 100% for obstetric cases.
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Interaction between digoxin and tricyclic antidepressants in the rat.
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