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The relevance of the CD4+ CD26– subset in the identification of circulating Sézary cells
Background  The lack of specific markers for the phenotyping of circulating neoplastic T cells in Sézary syndrome (SS) patients makes it difficult both to ascertain the presence of clonal cells andExpand
Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab.
Baseline neutrophils and derived neutrophilto-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab P. F. Ferrucci1, P. A. Ascierto2, J. Pigozzo3, M. DelExpand
Clinical and prognostic reports from 270 patients with multiple primary melanomas: a 34‐year single‐institution study
TLDR
Developing more than one primary melanoma in a sole patient is frequent, accounting for 1.2–8.2% of melanoma patients in most recent series. Expand
Vitiligo is an independent favourable prognostic factor in stage III and IV metastatic melanoma patients: results from a single-institution hospital-based observational cohort study.
TLDR
Melanoma-associated vitiligo should be considered as a distinct clinical entity, separate from Vitiligo vulgaris, and identifies a subgroup of patients characterised by a high prevalence of immune-mediated diseases and by a favourable prognosis. Expand
Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin.
TLDR
Multiple alterations of integrins are also present in uninvolved keratinocytes from psoriatic patients, suggesting a key role for altered integrin-mediated adhesion in the pathogenesis of this disease. Expand
Prognostic relevance of baseline and sequential peripheral blood tyrosinase expression in 200 consecutive advanced metastatic melanoma patients
TLDR
Results demonstrate that the discrepancies in the positive tyrosinase rates reported in the literature are related to the disease status at the time of sampling and to chemotherapy administration and were shown to be the most significant prognostic parameter associated to both overall survival and time to progression. Expand
Electrochemotherapy with Intravenous Bleomycin in the Local Treatment of Skin Melanoma Metastases
TLDR
ECT is a safe procedure, easily performed in terms of toxicities and cost-effectiveness ratios, and constitutes a therapeutic tool for relapsed/refractory cutaneous melanoma patients, and the repeated ECT sessions are associated with a response increase in re-treated lesions which could allow to overcome the reduced activity in >1 cm2 sized metastases. Expand
Melanoma of unknown primary site: a 33-year experience at the Turin Melanoma Centre
TLDR
The relatively good prognosis of unknown primary melanoma patients is confirmed, a fact that has to be taken into consideration for their management. Expand
Blood flow cytometry in Sézary syndrome: new insights on prognostic relevance and immunophenotypic changes during follow-up.
TLDR
The relevance of CD26 negativity in SS diagnosis and monitoring is confirmed and the presence of rare CD26+ cases suggests that a multiparameter flow cytometry approach should be used. Expand
Anti-oxidative effects of 17 β-estradiol and genistein in human skin fibroblasts and keratinocytes.
TLDR
17 β-estradiol/genistein protected fibroblasts/keratinocytes against peroxidation by modulating oxidant/antioxidant system and mitochondria membrane potential, through mechanisms related to ERs and GPER30 and kinases activation. Expand
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