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A rapid micromethod for the determination of ascorbic acid in plasma and tissues.
Abstract A rapid simple micromethod for the determination of l -ascorbic acid in plasma and other biological tissues using orthophosphoric acid and ferric iron is presented. The ferric iron isExpand
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Catalytic activity of administered gulonolactone oxidase polyethylene glycol conjugates.
Scurvy in guinea pigs provides a convenient model of inborn metabolic disease for the investigation of enzyme therapy protocols. Gulonolactone oxidase, the enzyme in ascorbic acid biosynthesis thatExpand
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Ascorbic acid: an endogenous inhibitor of isolated Na+,K+-ATPase.
During attempts to isolate and identify an endogenous ligand for the glycoside binding sites on Na+,K+-ATPase, bovine adrenal glands were found to contain a potent inhibitor of isolatedExpand
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  • V. Zannoni, P. Sato
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1 September 1975
Studies from a number of laboratories have shown that vitamin C deficiency in guinea pigs results in decreased metabolism of a variety of pharmacological agents.'-'" In 1941, Richards et al.' found aExpand
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Ascorbic acid and hepatic drug metabolism.
  • P. Sato, V. Zannoni
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 August 1976
Previous in vivo studies indicate that hepatic microsomal drug metabolism decreases in ascorbic acid deficiency and is augmented when high supplements of the vitamin are given to guinea pigs. KineticExpand
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Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury
Abstract: Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21‐aminosteroidExpand
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Glutaraldehyde-reacted immunoprecipitates of L-gulonolactone oxidase are suitable for administration to guinea pigs.
The potential pharmacologic use of enzymes has long been considered. Practical applications, however, have been limited by the toxicity and allergic response to administered foreign proteins. AExpand
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Renal L-gulono-1,4-lactone oxidase activity as affected by dietary ascorbic acid in lake sturgeon (Acipenser fulvescens)
Abstract Sturgeon can synthesize l -ascorbic acid (vitamin C) as they possess in their kidney l -gulono-1,4-lactone oxidase, the enzyme catalyzing the last step of AA biosynthesis. The effect ofExpand
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A protocol for the successful long-term enzyme replacement therapy of scurvy in guinea pigs
  • K. Hadley, P. Sato
  • Biology, Medicine
  • Journal of Inherited Metabolic Disease
  • 1 December 1988
SummaryGulonolactone oxidase, a key enzyme in the biosynthesis of ascorbic acid, is missing from guinea pigs and certain other scurvy-prone species. Weekly intraperitoneal injections ofExpand
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Studies on ascorbic acid related to the genetic basis of scurvy.
Publisher Summary This chapter presents the studies on ascorbic acid related to the genetic basis of scurvy. The importance of ascorbic acid has long been known, scurvy being the first recognizedExpand
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