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Loss of Parkinson’s susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis
TLDR
In patients, reduced LRRK2 was significantly associated with ongoing smoking and worse survival, as well as signatures of less differentiated LUAD, altered surfactant metabolism and immunosuppression, and shared transcriptional signals between L RRK2-low LUAD and postnatal alveolarization in mice were identified, suggesting aberrant activation of a developmental program ofAlveolar growth and differentiation in these tumors.
Evolution of tools and methods for monitoring autophagic flux in mammalian cells.
TLDR
The tools and methods used in mammalian cultured cells pertaining to these two approaches are summarized, innovations that have led to their evolution in recent years are highlighted, and the potential limitations of these approaches are discussed.
Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?
TLDR
This one-day symposium was held at the BC Cancer Research Centre in Vancouver, BC, bringing together experts in cell biology, protein biochemistry and medicinal chemistry across several different disease models and model organisms.
Investigating autophagy and glutamine metabolism as therapeutic targets for pancreatic cancer.
TLDR
Novel combination therapy approaches based on the inhibition of glutamine metabolism and autophagy, to improve current treatments for PDAC are developed, since both processes are key mediators of multiple cancer hallmarks.
Abstract PO-044: ATG4B loss reduces pancreatic cancer cell viability and enhances the utilization of survival-promoting GABARAP-L2
TLDR
This finding indicates that GABarAP-L2 is required for the survival of MiaPaca2 cells, and further analyses of GABARAP- L2 in PDAC and normal pancreatic cell lines are in progress.