P. Sarret

Publications165
h-index35
Citations3,386
Highly Influential Citations154
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CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury
CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development. We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from afferents in the dorsal horn… Expand
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Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist‐treated rats
A better understanding of the mechanisms linked to chemokine pronociceptive effects is essential for the development of new strategies to better prevent and treat chronic pain. Among chemokines,… Expand
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Immunohistochemical distribution of NTS2 neurotensin receptors in the rat central nervous system
In the present study, we localized the levocabastine‐sensitive neurotensin receptor (NTS2) protein in adult rat brain by using an N‐terminally‐directed antibody. NTS2‐like immunoreactivity was… Expand
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Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain
This work describes the cloning and expression of the levocabastine-sensitive neurotensin (NT) receptor from mouse brain. The receptor protein comprises 417 amino acids and bears the characteristics… Expand
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Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin
The neuropeptide neurotensin (NT) elicits hypothermic and naloxone-insensitive analgesic responses after brain injection. Recent pharmacological evidence obtained with NT agonists and antagonists… Expand
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Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system
The neurotensin (NT) receptor, NTS3, originally identified as the intracellular sorting protein sortilin, is a member of a recently discovered family of receptors characterized by a single… Expand
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Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats
Preclinical pain assessment remains a key step for the development of new and potent painkillers. Significant progress in pain evaluation has been achieved with the development of non-reflexive… Expand
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Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.
ELABELA (ELA) was recently discovered as a novel endogenous ligand of the apelin receptor (APJ), a G protein-coupled receptor. ELA signaling was demonstrated to be crucial for normal heart and… Expand
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Somatostatin-Induced Regulation of SST2A Receptor Expression and Cell Surface Availability in Central Neurons: Role of Receptor Internalization
To investigate the effects of somatostatin (somatotropin release-inhibiting factor, SRIF) on the regulation of SST2A receptors in mammalian brain, we examined how blockade of SRIF release or… Expand
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Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
BackgroundCentral neurotensin (NT) administration results in a naloxone-insensitive antinociceptive response in animal models of acute and persistent pain. Both NTS1 and NTS2 receptors were shown to… Expand
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