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Localization of Members of the γ-Glutamyl Transpeptidase Family Identifies Sites of Glutathione and Glutathione S-Conjugate Hydrolysis1[W][OA]
TLDR
By analyzing the expression of each GGT in plants containing GGT:β-glucuronidase fusions, the temporal and spatial pattern of degradation of glutathione and its metabolites was established, revealing appreciable overlap among GGTs. Expand
Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer
TLDR
The data indicate that endoxifen formation in premenopausal women depends on CYP2D6 irrespective of ethnicity, and low endoxIFen concentration/formation and decreased CYP 2D6 activity predict shorter DRFS. Expand
Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein
TLDR
It is demonstrated that NC chaperone activity has a major role in ensuring the fidelity of plus-strand priming in HIV-1 nucleocapsid protein-based reverse transcription. Expand
Impact of metabolizing enzymes on drug response of endocrine therapy in breast cancer
TLDR
The authors will discuss the current evidence on the most important metabolizing enzymes in endocrine therapy, with a special focus on CYP2D6 and its role in tamoxifen metabolism. Expand
Clinical outcome and global gene expression data support the existence of the estrogen receptor-negative/progesterone receptor-positive invasive breast cancer phenotype
TLDR
The notion of the existence of an ER−/PR+ phenotype with clinical and molecular features distinct from the large group of ER+/ PR+ patients is supported. Expand
Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment
TLDR
Tamoxifen-induced change in PMD appears to have a genetic component, and was found to be significantly associated with the degree of CYP2D6 enzyme functionality. Expand
Abstract 2671: CYP2D6 polymorphisms are not associated with tamoxifen outcome in premenopausal women with ER positive breast cancer of the POSH cohort
TLDR
The Prospective Study of Outcomes in Sporadic versus Hereditary Breast Cancer (POSH) collection was used to explore the pharmacogenetic relationship between CYP2D6 polymorphisms and tamoxifen outcome in premenopausal patients, and it was found that variation in the metabolism and cytotoxic effects of these agents may mask CYP1D6 dependent tamoxIFen outcome. Expand
CYP2D6: interethnic variability
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