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Human Leukocyte Antigen‐G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells
Adult bone marrow‐derived mesenchymal stem cells (MSCs) are multipotent cells that are the subject of intense investigation in regenerative medicine. In addition, MSCs possess immunomodulatory… Expand
CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells
- S. Perruche, P. Zhang, Yongzhong Liu, P. Saas, J. Bluestone, W. Chen
- Nature Medicine
- 1 May 2008
Intact CD3-specific antibody transiently depletes large numbers of T cells and subsequently induces long-term immune tolerance. The underlying mechanisms for the systemic tolerance, however, remain… Expand
Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft.
Administration of donor T cells expressing the herpes simplex-thymidine kinase (HS-tk) with a hematopoietic stem cell (HSC) transplantation could allow, if graft-versus-host disease (GVHD) was to… Expand
Relevance of Toll-like receptor-4 polymorphisms in renal transplantation.
BACKGROUND Polymorphisms in Toll-like receptor-4 (TLR4) have been reported to be associated with a blunted immune response to microbial pathogens, as well as a decreased risk of atherosclerosis in… Expand
Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners.
- J. Brugniaux, L. Schmitt, +10 authors J. Richalet
- Chemistry, Medicine
- Journal of applied physiology
The efficiency of "living high, training low" (LHTL) remains controversial, despite its wide utilization. This study aimed to verify whether maximal and/or submaximal aerobic performance were… Expand
Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.
Several different tumor types have recently been shown to express functional Fas ligand (FasL), which may represent an additional mechanism of tumor escape. However, the in vivo significance of these… Expand
CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation?
- P. Saas, J. Boucraut, +6 authors P. Y. Dietrich
- Biology, Medicine
- Journal of immunology
- 15 February 1999
Astrocytes are a major cellular component of the brain that are capable of intense proliferation and metabolic activity during diverse inflammatory brain diseases (such as multiple sclerosis,… Expand
Plasmacytoid dendritic cell leukaemia/lymphoma: towards a well defined entity?
CD4+/CD56+ haematodermic neoplasm or ‘early’ plasmacytoid dendritic cell leukaemia/lymphoma (pDCL) was described as a disease entity in the last World Health Organisation/European Organisation for… Expand
Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes.
- Emilie Brillard, J. Pallandre, +8 authors C. Borg
- Medicine, Biology
- Experimental hematology
- 1 March 2007
OBJECTIVE CD4(+)CD25(+) regulatory T lymphocytes (Treg) have been initially shown to prevent organ-specific autoimmunity. It is now accepted that Treg homeostasis depends in part on the peripheral… Expand
Cytomegalovirus exposure and cardiovascular disease in kidney transplant recipients.
- C. Courivaud, J. Bamoulid, +4 authors D. Ducloux
- The Journal of infectious diseases
- 15 May 2013
Some data suggest that cytomegalovirus (CMV) may be involved in atherogenesis. However, there are few data suggesting that CMV may contribute to posttransplantation atherosclerosis. We studied a… Expand