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Novel glial‐neuronal signalling by coactivation of metabotropic glutamate and beta‐adrenergic receptors in rat hippocampus.
1. We have previously reported that activation of group II‐like metabotropic glutamate receptors (mGluRs) in rat hippocampus results in a potentiation of the accumulation of cAMP elicited byExpand
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Phase I trial of an oral immunomodulator and interferon inducer in cancer patients.
Imiquimod [1-(2-methylpropyl)-1H-imidazo[4,5c]quinolin-4-amine] is a compound of low molecular weight that, when administered p.o., induces interferon-alpha in several animal species and inhibitsExpand
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Neuregulin‐1 enhances survival of human astrocytic glioma cells
Malignant astrocytic gliomas, referred to as astrocytomas, represent the most commonly diagnosed adult primary brain tumor. These tumors are characterized by unrelenting growth that is oftenExpand
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Increased relative effectiveness of doxorubicin against slowly proliferating sarcoma 180 cells after prolonged drug exposure.
Doxorubicin (ADR) lethality was studied in Sarcoma 180 cells grown in vitro during log phase and early plateau phase. For both log phase and plateau phase cells, ADR lethality increased progressivelyExpand
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Schedule optimization of hydroxyurea and 1-beta-D-arabinofuranosylcytosine in sarcoma 180 in vitro.
Abstract The lethal and sublethal effects of 1-β-d-arabinofuranosylcytosine (ara-C) were studied in Sarcoma 180 in vitro in relation to drug concentration and drug exposure duration. Drug lethalityExpand
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A practical graphical method for estimating the fraction of cells in S in DNA histograms from clinical tumor samples containing aneuploid cell populations.
A graphical method for the analysis of unperturbed DNA histograms is presented in which the area of the normalized histogram subtended by the fraction of cells in S is represented by a trapezoidExpand
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Kinetic effects of sangivamycin in sarcoma 180 in vitro.
The lethal and sublethal effects of sangivamycin (SGM) were studied in sarcoma 180 in vitro in relation to drug concentration and duration of drug exposure. SGM lethality was found to be dependent onExpand
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Cis‐dichlorodiammineplatinum II‐induced syndrome of inappropriate secretion of antidiuretic hormone
A patient with glioblastoma multiforme developed hyponatremia. This was accompanied by decreased mental awareness and seizures following cis‐dichlorodiammine platinum II (DDP) chemotherapy. TreatmentExpand
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Schedule-dependent synergism of combinations of hydroxyurea with adriamycin and 1-beta-D-arabinofuranosylcytosine with adriamycin.
The lethal effects of combinations of adriamycin (ADR) and either hydroxyurea (HU) or 1-beta-d-arabinofuranosylcytosine (ara-C) were studied in relation to drug-scheduling interval in Sarcoma 180Expand
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Modulation of glioma BK channels via erbB2
Glioma cells show up‐regulation and constitutive activation of erbB2, and its expression correlates positively with increased malignancy. A similar correlation has been demonstrated for theExpand
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