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N-Acylhydrazones as drugs.
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and futureExpand
Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40)
G‐protein‐coupled receptor 40 (GPR40) was recently identified as an interesting target for treatment of type 2 diabetes. The high level of expression in pancreatic beta cells and the dependence ofExpand
Theoretical and experimental characterization of 1,4-N⋯S σ-hole intramolecular interactions in bioactive N-acylhydrazone derivatives
Sigma-hole (σ-hole) bonds are interactions that are gaining special attention in medicinal chemistry. This type of interaction, initially assigned to the halogens (group 17 of the periodic table),Expand
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities
Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment, several works in the literature have shown that these inhibitors can be used in several other diseases, suchExpand
An Unusual Intramolecular Halogen Bond Guides Conformational Selection.
PIK-75 is a phosphoinositide-3-kinase (PI3K) α-isoform-selective inhibitor with high potency. Although published structure-activity relationship data show the importance of the NO2 and the BrExpand
Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol‐3‐kinase (PI3K): Current and Future Prospects
The discovery of histone deacetylase (HDAC) inhibitors is a hot topic in the medicinal chemistry community regarding cancer research. This is related primarily to two factors: success in the clinic,Expand
CCDC 1848022: Experimental Crystal Structure Determination
Related Article: Roberta Tesch, Christian Becker, Matthias Philipp Muller, Michael Edmund Beck, Lena Quambusch, Matthaus Getlik, Jonas Lategahn, Niklas Uhlenbrock, Fanny Nascimento Costa, Marcelo D.Expand
Structure–property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety
Conformational stabilization mediated by hydrogen bonds can play an important role in the drug-target recognition process. Non-classical hydrogen bonding is receiving great attention, where C–H⋯YExpand