• Publications
  • Influence
General Anesthetic Actions on GABAA Receptors
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years,Expand
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Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors
A component of cerebrospinal fluid in excessively sleepy people activates an inhibitory signaling pathway and mimics the actions of sedative-hypnotics. Awake and Refreshed A spindle prick on theExpand
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Postoperative cognitive dysfunction, Alzheimer's disease, and anesthesia
Although aging itself is not a disease, there are many comorbidities that become more common with aging. Heart disease, cancer, and other chronic illnesses are either more common or more severe inExpand
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Electroencephalographic Variation during End Maintenance and Emergence from Surgical Anesthesia
The re-establishment of conscious awareness after discontinuing general anesthesia has often been assumed to be the inverse of loss of consciousness. This is despite the obvious asymmetry in theExpand
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Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience
The macrolide antibiotic clarithromycin can enhance central nervous system excitability, possibly by antagonism of GABA-A receptors. Enhancement of GABA signaling has recently been demonstrated in aExpand
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Emergence from general anesthesia and the sleep-manifold
The electroencephalogram (EEG) during the re-establishment of consciousness after general anesthesia and surgery varies starkly between patients. Can the EEG during this emergence period provide aExpand
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The role of thrombin and protease-activated receptors in pain mechanisms.
As our knowledge of the mechanisms underlying the sensation of pain continues to expand, researchers are constantly searching for novel therapeutic targets. One such novel pain pathway involvesExpand
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A central pattern generator producing alternative outputs: pattern, strength, and dynamics of premotor synaptic input to leech heart motor neurons.
The central pattern generator (CPG) for heartbeat in medicinal leeches consists of seven identified pairs of segmental heart interneurons and one unidentified pair. Four of the identified pairs andExpand
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Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling.
Antibiotics are used in the treatment and prevention of bacterial infections, but effects on neuron excitability have been documented. A recent study demonstrated that clarithromycin alleviatesExpand
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Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity
Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation. However, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), haveExpand
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