P. S. Garcia
Author pages are created from data sourced from our academic publisher partnerships and public sources.
General Anesthetic Actions on GABAA Receptors
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years,… Expand
Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors
- D. Rye, Donald L. Bliwise, +8 authors A. Jenkins
- Medicine, Biology
- Science Translational Medicine
- 21 November 2012
A component of cerebrospinal fluid in excessively sleepy people activates an inhibitory signaling pathway and mimics the actions of sedative-hypnotics. Awake and Refreshed A spindle prick on the… Expand
Postoperative cognitive dysfunction, Alzheimer's disease, and anesthesia
- Sona S Arora, Jennifer L Gooch, P. S. Garcia
- The International journal of neuroscience
- 1 April 2014
Although aging itself is not a disease, there are many comorbidities that become more common with aging. Heart disease, cancer, and other chronic illnesses are either more common or more severe in… Expand
Electroencephalographic Variation during End Maintenance and Emergence from Surgical Anesthesia
The re-establishment of conscious awareness after discontinuing general anesthesia has often been assumed to be the inverse of loss of consciousness. This is despite the obvious asymmetry in the… Expand
Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience
- L. M. Trotti, Prabhjyot Saini, +4 authors D. Rye
- Medicine, Psychology
- Journal of psychopharmacology
- 1 July 2014
The macrolide antibiotic clarithromycin can enhance central nervous system excitability, possibly by antagonism of GABA-A receptors. Enhancement of GABA signaling has recently been demonstrated in a… Expand
Emergence from general anesthesia and the sleep-manifold
- D. Hight, V. Dadok, A. Szeri, P. S. Garcia, L. Voss, J. Sleigh
- Psychology, Medicine
- Front. Syst. Neurosci.
- 13 August 2014
The electroencephalogram (EEG) during the re-establishment of consciousness after general anesthesia and surgery varies starkly between patients. Can the EEG during this emergence period provide a… Expand
The role of thrombin and protease-activated receptors in pain mechanisms.
As our knowledge of the mechanisms underlying the sensation of pain continues to expand, researchers are constantly searching for novel therapeutic targets. One such novel pain pathway involves… Expand
A central pattern generator producing alternative outputs: pattern, strength, and dynamics of premotor synaptic input to leech heart motor neurons.
- B. Norris, Adam L. Weaver, A. Wenning, P. S. Garcia, R. Calabrese
- Psychology, Medicine
- Journal of neurophysiology
- 1 November 2007
The central pattern generator (CPG) for heartbeat in medicinal leeches consists of seven identified pairs of segmental heart interneurons and one unidentified pair. Four of the identified pairs and… Expand
Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling.
Antibiotics are used in the treatment and prevention of bacterial infections, but effects on neuron excitability have been documented. A recent study demonstrated that clarithromycin alleviates… Expand
Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity
Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation. However, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), have… Expand