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Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease
TLDR
Cerebral cortical signal increase and high signal in caudate nucleus and putamen on fluid attenuated inversion recovery or diffusion-weight imaging magnetic resonance imaging are useful in the diagnosis of sporadic Creutzfeldt–Jakob disease. Expand
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
TLDR
A large genome-wide association meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism. Expand
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
TLDR
Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positron emission tomography or cerebrospinal fluid findings was associated with age, apolipoprotein E [APOE] genotype, sex, and education, and presence of cognitive impairment. Expand
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
TLDR
Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease. Expand
CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease
TLDR
The detection of elevated levels of brain-derived proteins in the CSF in patients with suspected Creutzfeldt-Jakob disease is a valuable diagnostic test and a second lumbar puncture may be of value in patientswith atypical clinical course in whom the first test was negative. Expand
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
TLDR
Findings indicate the potential clinical utility of amyloid imaging for differential diagnosis in early-onset dementia and to support the clinical diagnosis of participants with AD dementia and noncarrier APOE ε4 status. Expand
Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease
TLDR
The findings suggest that inflammation in the CNS increases in normal aging and is intimately related to markers of neurodegeneration in the preclinical stages of AD and SNAP. Expand
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population.
TLDR
With use of cognitive function as an endophenotype of AD, this study indicates the that the RGSL2, RALGPS2, and C1orf49 genes are the potential disease-causing genes at 1q25. Expand
Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease
TLDR
This work assessed whether a genetic risk score (GRS), based on eight non-APOE genetic variants previously associated with AD risk in genome-wide association studies, is associated with either risk of conversion or with rapid progression from MCI to AD. Expand
MRI lesion profiles in sporadic Creutzfeldt–Jakob disease
TLDR
It is argued that characteristic MRI lesion patterns may occur for each molecular subtype of Creutzfeldt–Jakob disease. Expand
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