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Expression of osteoclast differentiation factor at sites of bone erosion in collagen-induced arthritis.
OBJECTIVE To investigate the cellular mechanism of bone destruction in collagen-induced arthritis (CIA). METHODS After induction of CIA in DA rats, a histologic study of the advanced arthriticExpand
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Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with methotrexate.
OBJECTIVE To determine cancer risk in a cohort of 459 rheumatoid arthritis (RA) patients treated with methotrexate in community practice. METHODS All RA patients who started methotrexate prior toExpand
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Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis.
Rheumatoid arthritis is characterized by progressive synovial inflammation and joint destruction. While matrix metalloproteinases (MMPs) are implicated in the erosion of unmineralized cartilage, boneExpand
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Methotrexate therapy in rheumatoid arthritis: a life table review of 587 patients treated in community practice.
To determine whether methotrexate (MTX) maintains its effectiveness in rheumatoid arthritis (RA) in the setting of community based private rheumatology practice we used life table analysis to reviewExpand
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Collagen induced arthritis in rats. Contrasting effect of subcutaneous versus intradermal inoculation of type II collagen.
OBJECTIVE To determine the effect of subcutaneous (s.c.) as compared to intradermal (i.d.) inoculation of collagen type II (CII) in induction of collagen induced arthritis (CIA). METHODS DarkExpand
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Adult-onset Still's disease. Twenty-year followup and further studies of patients with active disease.
Eleven female patients with adult-onset Still's disease were followed for 7-36 years (mean 20.2 years) after the onset of their illness. Ten of these patients had a chronic course characterized byExpand
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A case of certolizumab-induced interstitial lung disease in a patient with rheumatoid arthritis.
SIR, A 66-year-old non-smoking woman with a 35-year history of widespread erosive RA presented with rapidly progressive breathlessness. Her previous therapy had included CYC in the early 1990s,Expand
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Concurrent systemic lupus erythematosus and salmonellosis.
Salmonellosis was diagnosed in 4 patients with systemic lupus erythematosus (SLE). Three patients were taking prednisolone, and 3 had evidence of nephritis. All patients were febrile with clinicalExpand
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Thrombotic thrombocytopenic purpura, an acute clinical disorder of uncertain aetiology, has previously been associated with almost 100% mortality. Dramatic response to exchange transfusion has beenExpand
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