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Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.
  • M. Sausbier, H. Hu, +14 authors P. Ruth
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 22 June 2004
Malfunctions of potassium channels are increasingly implicated as causes of neurological disorders. However, the functional roles of the large-conductance voltage- and Ca(2+)-activated K(+) channelExpand
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Primary structure and functional expression from complementary DNA of a brain calcium channel
The primary structure of a voltage-dependent cal-cium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA isExpand
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Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ
Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells. Calcium release from inositolExpand
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Functionally Diverse Complement of Large Conductance Calcium- and Voltage-activated Potassium Channel (BK) α-Subunits Generated from a Single Site of Splicing*[boxs]
The pore-forming α-subunits of large conductance calcium- and voltage-activated potassium (BK) channels are encoded by a single gene that undergoes extensive alternative pre-mRNA splicing. However,Expand
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Dual role of protein kinase C on BK channel regulation
Large conductance voltage- and Ca2+-activated potassium channels (BK channels) are important feedback regulators in excitable cells and are potently regulated by protein kinases. The present studyExpand
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Structure and function of cGMP-dependent protein kinases.
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Ca2+-activated K+ channels of the BK-type in the mouse brain
An antibody against the 442 carboxy-terminal amino acids of the BK channel α-subunit detects high immunoreactivity within the telencephalon in cerebral cortices, olfactory bulb, basal ganglia andExpand
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A Molecular Switch for Specific Stimulation of the BKCa Channel by cGMP and cAMP Kinase*
The cGMP and the cAMP pathways control smooth muscle tone by regulation of BKCa (BK) channel activity. BK channels show considerable diversity and plasticity in their regulation by cyclicExpand
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Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels*
Background: Enzymes controlling (de)palmitoylation of ion channels are poorly defined. Results: Palmitoylation of BK channels by zDHHC22 and zDHHC23 and depalmitoylation by LYPLA1 and LYPLAL1Expand
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Otoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair Cells
The encoding of auditory information with indefatigable precision requires efficient resupply of vesicles at inner hair cell (IHC) ribbon synapses. Otoferlin, a transmembrane protein responsible forExpand
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