P. Ruiz-Lozano

Publications56
h-index31
Citations6,592
Highly Influential Citations323
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MicroRNA-133 controls cardiac hypertrophy
Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell functions and oncogenesis. Here we report that miR-133 has a critical role in determining cardiomyocyte… Expand
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Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
The embryonic cellular events that set the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination in mammals are poorly understood. New insight into this problem was… Expand
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T-cadherin is critical for adiponectin-mediated cardioprotection in mice.
The circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on the heart under stress conditions. The receptors binding APN to cardiac tissue, however, have remained… Expand
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Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation.
Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as the… Expand
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Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
The murine dishevelled 2 (Dvl2) gene is an ortholog of the Drosophila segment polarity gene Dishevelled, a member of the highly conserved Wingless/Wnt developmental pathway. Dvl2-deficient mice were… Expand
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Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1.
Asymmetric expression of Sonic hedgehog (Shh) in Hensen's node of the chicken embryo plays a key role in the genetic cascade that controls left-right asymmetry, but its involvement in left-right… Expand
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Epicardial retinoid X receptor is required for myocardial growth and coronary artery formation
Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor α (RXRα), as the systemic… Expand
  • 280
  • 13
Signaling via the Tgf-beta type I receptor Alk5 in heart development.
Trophic factors secreted both from the endocardium and epicardium regulate appropriate growth of the myocardium during cardiac development. Epicardially-derived cells play also a key role in… Expand
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A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
The role of the cardiac myocyte as a mediator of paracrine signaling in the heart has remained unclear. To address this issue, we generated mice with cardiac myocyte-specific deletion of the vascular… Expand
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Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent… Expand
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