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Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura.
TLDR
Intrinsic abnormalities of the complement system and of the von Willebrand factor pathway may account for a genetic predisposition to the disease that may play a paramount role in particular in familial and recurrent forms of HUS.
Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts.
TLDR
Lower eGFR and more severe albuminuria independently predict mortality and ESRD among individuals selected for CKD, with the associations stronger for E SRD than for mortality.
Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG).
TLDR
Dual transplants of marginal kidneys are as safe and tolerated as single transplants, and possibly offer an improved filtration power without exposing the recipient to enhanced risk of delayed renal function recovery, acute allograft rejection, or major surgical complications.
Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate.
TLDR
A significant correlation between the plasma clearance of iohexol and the renal clearance of inulin over a wide range of GFR values was found and a simplified method that uses a one-compartment model corrected with the Bröchner-Mortensen formula, an excellent correlation was observed.
Understanding the nature of renal disease progression.
Animal and human proteinuric glomerulopathies evolve to terminal renal failure by a process leading to progressive parenchymal damage, which appears to be relatively independent of the initial
Dynamics of complement activation in aHUS and how to monitor eculizumab therapy.
TLDR
Results point to efficient complement inhibition on endothelium for aHUS treatment, including C5b-9 endothelial deposits, which might help monitor eculizumab effectiveness, avoid drug overexposure, and save money considering the extremely high cost of the drug.
Preventing microalbuminuria in type 2 diabetes.
TLDR
In subjects with type 2 diabetes and hypertension but with normoalbuminuria, the use of trandolapril plus verapamil and trandOLapril alone decreased the incidence of micro Albuminuria to a similar extent to that of placebo.
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