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Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies
ABSTRACT Trypanosomiasis and leishmaniasis are important parasitic diseases affecting millions of people in Africa, Asia, and South America. In a previous study, we identified several flavonoidExpand
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Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
After the discovery of a potent natural flavonoid glucoside as a potent inhibitor of FabI, a large flavonoid library was screened against three important enzymes (i.e., FabG, FabZ, and FabI) involvedExpand
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Scent marking within and between groups of wild banded mongooses
Scent marking is commonly described as a territorial behaviour, and scent marks might deter potential intruders from entering occupied areas. Conspecific neighbours present both a reproductive and aExpand
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Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI)Expand
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(6S)-Hydroxy-3-oxo-α-ionol glucosides from Capparis spinosa fruits
Abstract Two new (6 S )-hydroxy-3-oxo-α-ionol glucosides, together with corchoionoside C ((6 S ,9 S )-roseoside) and a prenyl glucoside, were isolated from mature fruits of Capparis spinosa . TheExpand
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Sorbitol and sucrose partitioning in the growing apple fruit
Summary Growing apple fruit is supplied with the C-assimilates sorbitol and sucrose produced in leaf photosynthesis. These C-sources enter fruit metabolism and accumulate as fructose, sucrose, malicExpand
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Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis.
Anti-plasmodial activity-guided fractionation of Phlomis brunneogaleata (Lamiaceae) led to the isolation of two new metabolites, the iridoid glycoside, brunneogaleatoside and a new pyrrolidiniumExpand
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Syringolin, a novel peptide elicitor from Pseudomonas syringae pv. syringae that induces resistance to Pyricularia oryzae in rice
Recognition by rice plants (Oryza sativa) of the nonhost pathogen Pseudomonas syringae pv. syringae leads to an active response ultimately resulting in local acquired resistance against the riceExpand
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Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.
The ethanolic root extract of Scrophularia lepidota, an endemic plant of the Turkish flora, has been investigated for its anti-protozoal and inhibitory effect towards plasmodial enoyl-ACP reductaseExpand
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1H-indole-3 acetonitrile glycosides from Capparis spinosa fruits
Abstract Two new glucose-containing 1 H -indole-3-acetonitrile compounds, capparilosides A and B, were isolated from mature fruits of Capparis spinosa . On the basis of spectral and chemicalExpand
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