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A Draft Sequence of the Neandertal Genome
Kissing Cousins Neandertals, our closest relatives, ranged across Europe and Southwest Asia before their extinction approximately 30,000 years ago. Green et al. (p. 710) report a draft sequence ofExpand
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Runs of homozygosity in European populations.
Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wideExpand
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SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 μM) comparedExpand
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Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes
Economic Ancient DNA Sequencing Analysis of ancient DNA is often limited by the availability of ancient material for sequencing. Briggs et al. (p. 318; see the news story by Pennisi) describe aExpand
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Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europe.
To investigate which aspects of contemporary human Y-chromosome variation in Europe are characteristic of primary colonization, late-glacial expansions from refuge areas, Neolithic dispersals, orExpand
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A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing
A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA generated from approximately 0.3Expand
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A signal, from human mtDNA, of postglacial recolonization in Europe.
Mitochondrial HVS-I sequences from 10,365 subjects belonging to 56 populations/geographical regions of western Eurasia and northern Africa were first surveyed for the presence of the T-->C transitionExpand
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A high-coverage Neandertal genome from Vindija Cave in Croatia
Revelations from a Vindija Neandertal genome Neandertals clearly interbred with the ancestors of non-African modern humans, but many questions remain about our closest ancient relatives. Prüfer etExpand
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A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe
The phylogenetic relationships of numerous branches within the core Y-chromosome haplogroup R-M207 support a West Asian origin of haplogroup R1b, its initial differentiation there followed by a rapidExpand
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Origin and diffusion of mtDNA haplogroup X.
A maximum parsimony tree of 21 complete mitochondrial DNA (mtDNA) sequences belonging to haplogroup X and the survey of the haplogroup-associated polymorphisms in 13,589 mtDNAs from Eurasia andExpand
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