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Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype
Airway remodelling is a critical feature of chronic bronchial diseases, characterised by aberrant repair of the epithelium and accumulation of fibroblasts, which contribute to extracellular matrix… Expand
Chronic Lung Allograft Dysfunction: A Systematic Review of Mechanisms
Abstract Chronic lung allograft dysfunction (CLAD) is the major limitation of long-term survival after lung transplantation. Chronic lung allograft dysfunction manifests as bronchiolitis obliterans… Expand
Spatio-temporal variability of the atmospheric boundary layer depth over the Paris agglomeration: An assessment of the impact of the urban heat island intensity
Abstract Within the framework of a French nationally funded project (CO 2 -MEGAPARIS) for quantifying the CO 2 emissions of the Paris area, a lidar-based experimental investigation of the variability… Expand
Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung
- S. Mouraux, E. Bernasconi, +314 authors J. Pellet
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 18 July 2017
Background: Homeostatic turnover of the extracellular matrix conditions the structure and function of the healthy lung. In lung transplantation, long‐term management remains limited by chronic lung… Expand
Efficient monocyte-derived dendritic cell generation in patients with acute myeloid leukemia after chemotherapy treatment: application to active immunotherapy.
OBJECTIVE While complete remission in acute myeloid leukemia (AML) can be achieved after chemotherapy (CT), relapses occur for the majority of patients, underlying the need to eliminate residual… Expand
Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome
- R. Danger, P. Royer, +23 authors J. J.-F. H. E. C. M. M. R. M. Y. F. G. L. J. S. D. J. Jougon Velly Rozé Blanchard Dromer Antoine Cappell
- Front. Immunol.
- 11 January 2018
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term survival after lung transplantation. Identifying predictors of BOS is… Expand
High circulating CD4+CD25hiFOXP3+ T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome.
- M. Durand, P. Lacoste, +20 authors S. Brouard
- The Journal of heart and lung transplantation…
- 20 March 2018
BACKGROUND Chronic bronchiolitis obliterans syndrome (BOS) remains a major limitation for long-term survival after lung transplantation. The immune mechanisms involved and predictive biomarkers have… Expand
Risk factors for chronic lung allograft dysfunction (CLAD) in the SysCLAD cohort
Introduction: CLAD and its phenotypes, Bronchiolitis Obliterans Syndrome (BOS) and Restrictive Allograft Syndrome (RAS) are major causes of mortality after lung transplantation (LT). Aims: To… Expand
Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses.
- Maria Dolores Lopez Robles, A. Pallier, +14 authors E. Chiffoleau
- Biology, Medicine
- Blood advances
- 28 March 2017
Dendritic cells (DCs) represent essential antigen-presenting cells that are critical for linking innate and adaptive immunity, and influencing T-cell responses. Among pattern recognition receptors,… Expand
Cohort characteristics and chronic lung allograft dysfunction (CLAD) adjudication in a FP-7 funded project, systems prediction of CLAD (SysCLAD)
Background : CLAD including restrictive allograft syndrome (RAS) and bronchiolitis obliterans syndrome (BOS)is the main limitation in long-term survival after lung transplantation (LT); no predictive… Expand