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Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
BACKGROUND The mechanisms by which hypertension causes vascular events are unclear. Guidelines for diagnosis and treatment focus only on underlying mean blood pressure. We aimed to reliably establishExpand
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External validity of randomised controlled trials: “To whom do the results of this trial apply?”
In making treatment decisions, doctors and patients must take into account relevant randomised controlled trials (RCTs) and systematic reviews. Relevance depends on external validity (orExpand
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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
BACKGROUND Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer. Several lines of evidence suggest that aspirin might also reduce risk of other cancers,Expand
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Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis
BACKGROUND Reliable data on the prevalence and predictors of post-stroke dementia are needed to inform patients and carers, plan services and clinical trials, ascertain the overall burden of stroke,Expand
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Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
BACKGROUND High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness ofExpand
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Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis
BACKGROUND Stroke is often preceded by transient ischaemic attack (TIA), but studies of stroke risk after TIA are logistically difficult and have yielded conflicting results. However, reliableExpand
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Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
BACKGROUND Daily aspirin reduces the long-term risk of death due to cancer. However, the short-term effect is less certain, especially in women, effects on cancer incidence are largely unknown, andExpand
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Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
BACKGROUND Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, suggesting that it might also reduceExpand
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Carotid artery disease and stroke during coronary artery bypass: a critical review of the literature.
OBJECTIVES to determine the role of carotid artery disease in the pathophysiology of stroke after coronary artery bypass (CABG). DESIGN systematic review of the literature. RESULTS the risk ofExpand
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