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Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.
TLDR
In evaluations of known polymorphisms in parasites from patients with uncomplicated malaria in Kampala, Uganda, the presence of 8 pfcrt mutations and 2 pfmdr-1 mutations did not correlate with clinical response to therapy with chloroquine, suggesting that other factors may contribute to clinical outcomes. Expand
Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.
TLDR
Patients who last took chloroquine 3 to 14 days prior to study entry were significantly more likely to be treatment failures compared to patients with very recent (less than 3 days) or no recent chlorquine use, and easily identifiable predictors of chloroquines treatment failure might be used to stratify patients. Expand
Difficulties in the prevention, diagnosis, and treatment of imported malaria.
TLDR
The results suggest that a standard chemoprophylactic regimen is highly effective in preventing falciparum malaria, but that many American travelers do not receive it and that the presentation of imported malaria is nonspecific, highlighting the need to consider the diagnosis in any febrile patient who has been in a malaria-endemic area. Expand
Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.
TLDR
The presence of a cyclohexyl substituent at N-1 and a phenyl group on the Triazole ring markedly improved the activity profiles of triazole-tethered β-lactam exhibiting IC(50) values of 1.13, 1.21 and 1.00 μM against 3D7, K1 and W2 strains respectively. Expand
Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure
TLDR
This work used detailed clinical and entomological data from parallel cohort studies conducted across the malaria transmission spectrum in Uganda to quantify the development of immunity against symptomatic P. falciparum as a function of age and transmission intensity. Expand
A new library of C-16 modified artemisinin analogs and evaluation of their anti-parasitic activities.
TLDR
A library of C-16 modified artemisinin analogs was prepared and their antimalarial as well as antileishmanial activities were evaluated, and a number of compounds were notably leishmanicidal, with activities comparable to or better than pentamidine. Expand
Malaria Transmission, Infection, and Disease following Sustained Indoor Residual Spraying of Insecticide in Tororo, Uganda.
TLDR
After 5 years of intensive vector control measures in Tororo, the burden of malaria was reduced to very low transmission levels, however, a significant proportion of the population remained parasitemic, primarily school-aged children with submicroscopic parasitemia, providing a potential reservoir for malaria transmission. Expand
Sex-based differences in clearance of chronic Plasmodium falciparum infection
TLDR
Differences in P. falciparum prevalence between males and females observed in endemic settings were driven by faster clearance rates in females and not by increased infection rates in males, implicate biological sex-based differences as an important factor in the host response to this globally important pathogen. Expand
Sex-based differences in clearance of chronic Plasmodium falciparum infection
TLDR
Findings implicate biological sex-based differences in host-parasite interactions as an important factor in the host response to this globally important pathogen. Expand
Arch Venez Med Trop
Al Consejo de Desarrollo Cientifi co y Humanistico (CDCH) de la Universidad Central de Venezuela (Proyectos PG 0630-5126-2.003 y PG 0630-5125- 2.003)) y a la Universidad Pedagogica ExperimentalExpand
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