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Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
TLDR
This method provides a basis for developing cell therapy strategies using expanded HSCs that are not genetically modified and takes advantage of the ability of HOX proteins to passively translocate through cell membranes to eliminate any deleterious effects.
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Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.
TLDR
This work cloned and characterized the human PBGD gene, which is split into 15 exons spread over 10 kilobases of DNA, and demonstrates that the two mRNAs arise from two overlapping transcription units.
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Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains
TLDR
The signaling sequence for nuclear localization of human GATA-3 is a property conferred by sequences within and surrounding the amino finger, thereby assigning a function to this domain and thus explaining the curious observation that this zinc finger is dispensable for DNA binding by the GATA family of transcription factors.
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ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
TLDR
The results suggest that the dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.
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A T‐cell specific TCR delta DNA binding protein is a member of the human GATA family.
TLDR
The results indicate that the activation of specific genes by hGATA1 or hGata3 is partly governed by the lineage expression of these two factors during haematopoiesis and that, in the T‐cell lineage, hGAT3 binds the human TCR delta gene enhancer and is involved in its expression.
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TGFbeta signaling in male germ cells regulates gonocyte quiescence and fertility in mice.
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A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
TLDR
It is shown that neuropilin-1, a receptor involved in axon guidance, was expressed by human DCs and resting T cells both in vitro and in vivo and mediates interactions betweenDCs and T cells that are essential for initiation of the primary immune response.
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Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene.
TLDR
Using UV cross-linking, it is shown that NF-E2 has a higher molecular weight than AP1, demonstrating that NF -E2 is not an erythroid-specific degradation product of AP1.
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NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.
TLDR
It is shown that coculture of primary human T-ALL with a mouse stromal cell line expressing the NOTCH ligand delta-like-1 (DL1) reproducibly allowed maintenance of T-LiC and long-term growth of blast cells.
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A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
TLDR
In the May 2002 issue of Nature Immunology, an incorrect version of Figure 3c was supplied and the correct version is shown below.
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