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High Resolution X-ray Crystallography Shows That Ascorbate Is a Cofactor for Myrosinase and Substitutes for the Function of the Catalytic Base*
Activation of the hydrolysis of the glucosyl enzyme intermediate is further evidenced by the observation that ascorbate enhances the rate of reactivation of the 2-fluoro-glycosyl enzyme, leading to the conclusion that asCorbic acid substitutes for the catalytic base in myrosinase. Expand
Isolation of 4-methylthio-3-butenyl glucosinolate from Raphanus sativus sprouts (kaiware daikon) and its redox properties.
The assessed reducing capacity of GRH suggests that R. sativus sprouts might possess potential for health benefits, and is related to its radical scavenging activity. Expand
The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo.
Investigation of in vitro and in vivo activity of glucomoringin (GMG), an uncommon member of the GLs family, showed that pure GMG-ITC was only slightly active in a carcinoma mice model, whereas it had significant antitumoral activity in a myeloma model, causing little toxicity. Expand
Comparison of bioactive phytochemical content and release of isothiocyanates in selected brassica sprouts.
The determination of the main constituents related to human health found in edible sprouts of two Brassica oleracea varieties, broccoli and Tuscan black kale, and two Raphanus sativus varieties, Daikon and Sango are reported. Expand
Original Synthesis of Linear, Branched and Cyclic Oligoglycerol Standards
A variety of authentic standards of linear, branched and cyclic oligomers of glycerol, with well-defined structures and degrees of polymerisation from 2 to 5, have been efficiently synthesised.Expand
Enzymatic, Chemical, and Thermal Breakdown of 3H-Labeled Glucobrassicin, the Parent Indole Glucosinolate
The enzymatic, chemical, and thermal breakdown pathways of glucobrassicin, the major indolylmethyl glucosinolate of cruciferous vegetables, have been studied using synthetic 3H-labeled glucobrassicinExpand
The Isothiocyanate Isolated from Moringa oleifera Shows Potent Anti-Inflammatory Activity in the Treatment of Murine Subacute Parkinson's Disease.
Results in vivo showed a higher efficacy of moringin compared with GMG not only to modulate the inflammatory pathway but also oxidative stress and apoptotic pathways, which can be used in clinical practice as a useful drug for the treatment or prevention of PD. Expand
Ability of a generalist insect, Schistocerca gregaria, to overcome thioglucoside defense in desert plants: tolerance or adaptation?
Desert locusts are generalist herbivores that, in the Sahara desert, may at times feed only on Schouwia purpurea (Forskål) (Brassicaceae), that is 10 times richer in thioglucosides than currently observed in other crucifers. Expand
The glucosinolate-myrosinase system. New insights into enzyme-substrate interactions by use of simplified inhibitors.
Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors of myrosinase inhibitors. Expand
Inhibition of the D-fructose transporter protein GLUT5 by fused-ring glyco-1,3-oxazolidin-2-thiones and -oxazolidin-2-ones.
In vitro, the fused-rings systems tested showed an efficient inhibition of GLUT5, thus bringing new insights on the interaction of D-fructose with GLUT7, the family of facilitating sugar transporters recently enlarged by the human genome sequencing. Expand