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Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
TLDR
Two ankylosing spondylitis–associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Expand
Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry
TLDR
It is found that glucocorticoid exposure of ≥10 mg/day is associated with a higher odds of hospitalisation and anti-TNF with a decreased odds ofospitalisation in patients with rheumatic disease. Expand
Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
TLDR
Among people with rheumatic disease, COVID-19-related death was associated with known general factors and disease-specific factors and the association with moderate/high disease activity highlights the importance of adequate disease control with DMARDs, preferably without increasing glucocorticoid dosages. Expand
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
TLDR
It is demonstrated that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA -B*40:01 carriers independently of HCA*27 genotype, and that in addition to effects due to HLA*27 alleles, several other Hla-B alleles also affect susceptibility. Expand
Intestinal Dysbiosis in Ankylosing Spondylitis
Objective. Ankylosing spondylitis (AS) is a common, highly heritable immune-mediated arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely ubiquitousExpand
Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis
TLDR
The aim of this study was to determine whether the gut in patients with AS carries a distinct microbial signature compared with that in the gut of healthy control subjects. Expand
Systematic review of the prevalence of gout and hyperuricaemia in Australia
TLDR
The aim of this study was to systematically review published information regarding the prevalence of gout and hyperuricaemia in Australia. Expand
Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis
To use high‐density genotyping to investigate the genetic associations of acute anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS).
Rothia aeria as a Cause of Sepsis in a Native Joint
TLDR
R. aeria is a recently described Gram-positive rod from the family Micrococcaceae that is characterizes this rare organism and contributes to the literature on its pathogenicity and likely oral source. Expand
An Observational Study of Gout Prevalence and Quality of Care in a National Australian General Practice Population
TLDR
Gout is managed poorly in Australian primary care, with low levels of allopurinol prescribing and serum urate testing, and these factors probably contribute to low achievement of serum Urate targets. Expand
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